ArticleJournal of gastrointestinal oncology2026
Single-nucleus RNA sequencing reveals the effects of key regulators on human pancreatic adenocarcinoma and its tumor microenvironment.
Article in Journal of gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The aggressive nature and poor prognosis of pancreatic ductal adenocarcinoma (PDAC) are closely linked to its complex tumor microenvironment (TME). However, a detailed mapping of the TME's cellular landscape and its interactions with cancer cells at single-cell resolution is still lacking, limiting our understanding of the disease. This study aims to utilize single-nucleus RNA sequencing technology to construct a panoramic single-cell transcriptomic map of the PDAC TME. Furthermore, the expression characteristics of the key differential genes Methods: To dissect the complex TME of PDAC, we employed single-nucleus RNA sequencing. By performing an integrated analysis of freshly collected and publicly available human PDAC samples, we identified a critical regulatory network involving Results: Tumor regions showed enrichment of acinar cells and depletion of fibroblasts and endothelial cells, reflecting epithelial and stromal remodeling. Ductal and acinar cells exhibited strong transcriptional reprogramming, with upregulation of Conclusions: Our work constructs a detailed single-cell transcriptomic atlas of the PDAC microenvironment. It implicates
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