Evidence map›Paper›PMID 42169799›Full record

ArticleOrthopaedic journal of sports medicine2026

Immune Cell Composition and Protein Biomarkers Correlate With PRP Treatment Outcomes in Knee Osteoarthritis.

Lea Zila, Juliane D Glaeser, Julia Sheyn, Giselle Kaneda, Jacob T Wechsler, Parnika Karthik, Victoria Yu, Jasmine Galloway, Begonya Comin-Anduix, Sarah Parker and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Orthopaedic journal of sports medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Lea ZilaOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.ORCID https://orcid.org/0009-0001-6159-5437
Juliane D GlaeserOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Julia SheynOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Giselle KanedaOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jacob T WechslerOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Parnika KarthikOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Victoria YuOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jasmine GallowayDepartment of Orthopaedics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Begonya Comin-AnduixDepartment of Surgery, University of California, Los Angeles, California, USA.
Sarah ParkerOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Aleksander StotlandOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Catherine BreseeOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Khosrowdad SalehiOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Pablo AvalosBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Clive N SvendsenBoard of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Wafa TawackoliOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Bert MandelbaumDepartment of Orthopaedics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Dmitriy SheynOrthopaedic Stem Cell Research Laboratory, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Funding

Studying the mechanism of discogenic low back pain induction.R01AR082041 · NIAMS · CEDARS-SINAI MEDICAL CENTER · PI SHEYN, DMITRIY · 2024 to 2025
$1.0M
NIAMS NIH HHS R01 AR082041
6 · The paper itself

Abstract

Background: Current treatments for osteoarthritis (OA) include physical therapy, nonsteroidal anti-inflammatory drugs, and joint arthroplasty, which aim to address symptoms rather than modify disease progression. Autologous platelet-rich plasma (PRP) and other biologics administered in the affected joint are widely used as alternatives that are believed to alleviate symptoms. However, PRP's effectiveness in reducing knee OA pain is inconsistent across the literature, and the specific therapeutic components remain unclear. Purpose: To identify whether specific cellular and protein biomarkers correlate with patient-reported outcomes and can therefore serve as predictive biomarkers for PRP effectiveness. Study Design: Case series; Level of evidence, 4. Methods: PRP samples from 30 patients (30 knees) with knee OA (Kellgren & Lawrence grades 2-3) who were undergoing PRP treatment were analyzed to identify biomarkers associated with response. Blood samples were drawn, and 2 identical PRP samples were prepared, with one set used for therapy and the other for analysis. Component analysis included cell counts, immune cell, and platelet characterization via mass cytometry, along with proteomic analysis using mass spectrometry. Clinical outcomes were assessed using the Knee injury and Osteoarthritis Outcome Score (KOOS) and Patient-Reported Outcomes Measurement Information System patient reported outcomes at baseline and up to 6 months postinjection. Results: PRP therapy improved pain in 19 of 30 patients at 6 weeks postinjection (mean ± SD age, 56.04 ± 10.56 years): Several distinct immune cell clusters (T helper 1 CD4 T cells ( Conclusion: These findings suggest that some cellular and protein biomarkers may potentially be used as therapeutic targets and predictive markers for PRP success, guiding personalized therapeutic strategies. However, these targets must be further validated for knee OA in future studies.

Indexed as

articular cartilagebiologic healing enhancementkneeplatelet rich plasma

Identifiers

PMID42169799
PMCPMC13187375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.