Evidence map›Paper›PMID 42169762›Full record

ArticleJournal of human immunity2025

Non-cryopreserved Kx negative packed red cell concentrates to support hematopoietic stem cell transplantation in McLeod contiguous gene deletion syndrome.

Julian Thalhammer, Charlotte Engström, Brigitte Strahm, Carsten Speckmann, Ayami Yoshimi, Andreas Scharberg, Elke Weinig, Marie-Christin Pauly, Markus Umhau, Stefan Meyer and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of human immunity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Julian ThalhammerCenter for Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-0226-1955
Charlotte EngströmBlood Transfusion Service Zurich, Swiss Red Cross, Schlieren, Switzerland.ORCID https://orcid.org/0009-0003-9591-9406
Brigitte StrahmCenter for Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-6086-130X
Carsten SpeckmannCenter for Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-6217-1556
Ayami YoshimiCenter for Pediatrics and Adolescent Medicine, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0003-1593-9507
Andreas ScharbergGerman Red Cross Blood Donor Service Baden-Württemberg-Hessen gGmbH Baden-Baden, Baden-Baden, Germany.ORCID https://orcid.org/0009-0009-4091-5516
Elke WeinigInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0009-0000-0647-9401
Marie-Christin PaulyInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0009-0008-6699-6927
Markus UmhauInstitute for Transfusion Medicine and Gene Therapy, Medical Center - University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0009-0002-7860-785X
Stefan MeyerBlood Transfusion Service Zurich, Swiss Red Cross, Schlieren, Switzerland.ORCID https://orcid.org/0000-0002-3098-9038
Stephan EhlInstitute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI) Medical Center - University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0002-9265-2721
Beat M Frey *Blood Transfusion Service Zurich, Swiss Red Cross, Schlieren, Switzerland.ORCID https://orcid.org/0000-0002-2514-8621
Richard Schäfer *Faculty of Medicine, University of Freiburg, Freiburg, Germany.ORCID https://orcid.org/0000-0003-1530-7980

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transfusion management of Kx- individuals with McLeod phenotype (MLP) is highly challenging, particularly as cryopreservation affects red blood cell (RBC) concentrate quality. We developed a concept to provide non-cryopreserved Kx- RBCs over the complete period of hematopoietic stem cell transplantation (HSCT) for treatment of X-linked chronic granulomatous disease (X-CGD) with MLP. An infant with a large deletion affecting 12 protein-coding genes, including

Identifiers

PMID42169762
PMCPMC13177374

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.