ArticleJournal of inflammation research2026
VIM Gene Variant Association to the Co-Occurrence of Livedoid Vasculopathy, Premature Canities, and Early-Onset Cataracts, and Preliminary Efficacy of Tofacitinib: A Case Report.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy characterized by ischemic lesions and painful skin ulcerations of the lower limbs. This report describes a male patient who presented with a novel co-presentation of LV, premature canities, and early-onset cataracts (EOC), a triad of symptoms not previously described in the context of Case Presentation: A 37-year-old male with an 8-year history of histopathologically confirmed LV also presented with premature canities and EOC. His mother had similar manifestations, including LV, premature canities, and EOC, suggesting a possible genetic etiology. Whole-exome sequencing revealed a heterozygous variant in the Conclusion: This case report highlights the first described co-presentation of a
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