ArticlePlastic and reconstructive surgery. Global open2026
Efficacy and Safety of the Use of Tranexamic Acid in Burn Patients: A Systematic Review and Meta-analysis.
Article in Plastic and reconstructive surgery. Global open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Tranexamic acid (TXA) is a widely used antifibrinolytic agent proven to reduce bleeding in many surgical settings. Its application in burn surgery is emerging; however, existing studies lack a comprehensive synthesis, making clinical translation challenging. Methods: A systematic review was conducted according to preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines and registered on PROSPERO (ID: CRD42023443397). An electronic search of PubMed, Ovid MEDLINE, and Embase (August 2024) yielded 532 articles, of which 15 studies met the inclusion criteria. Eligible study designs included randomized controlled trials, observational studies, case reports/series, and conference abstracts. Data on total blood loss, blood loss per area excised, hemoglobin levels, intraoperative fluid use, packed red blood cell transfusions, length of stay (LOS), complications, and mortality were extracted. Meta-analyses were performed using R (v4.4.1), and outcomes were reported as standardized mean differences (SMDs) or proportions. Results: Meta-analysis of 7 studies on preoperative intravenous TXA demonstrated significant reductions in total blood loss (SMD -0.65; Conclusions: Preoperative intravenous TXA may reduce surgical blood loss and intraoperative transfusions. Studies support a favorable safety profile. However, its impact on graft survival and overall transfusion needs is uncertain. Further research is warranted to optimize dosing, explore topical administration, and clarify subgroup effects.
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Registered trials
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