Evidence map›Paper›PMID 42169683›Full record

ArticleJournal of human immunity2026

Multigenerational SOCS1 insufficiency: Implications for the pathogenesis of allergic and autoimmune disease.

Cliodhna Murray, Michael J Harrison, Timothy R Leahy, Caríosa Lee-Brennan

Abstract read
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Cliodhna MurrayImmunology Department, Galway University Hospital, Galway, Ireland.ORCID https://orcid.org/0000-0001-9844-6294
Michael J HarrisonDepartment of Respiratory Medicine, Galway University Hospital, Galway, Ireland.ORCID https://orcid.org/0009-0009-7684-2291
Timothy R LeahyPaediatric Immunology, Children's Health Ireland, Dublin, Ireland.ORCID https://orcid.org/0000-0001-6419-9328
Caríosa Lee-BrennanImmunology Department, Galway University Hospital, Galway, Ireland.ORCID https://orcid.org/0009-0001-8846-8067

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This letter highlights diagnostic importance of considering monogenic immune dysregulation in complex allergic and autoimmune diseases. Additionally, the report expands on the clinical spectrum of suppressor of cytokine signaling 1 insufficiency (SOCS1 insufficiency) by identifying severe, treatment-refractory eosinophilic asthma as a novel primary manifestation.

Identifiers

PMID42169683
PMCPMC13177538

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.