How I Treat: Haploinsufficiency of A20.

Jonathan Li, Jeffrey Y Zhou, Manuel Carpio Tumba, Tingyan He, Kader Cetin Gedik, Daniella M Schwartz

Abstract readReview

In one paragraph

Review in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Jonathan LiDivision of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-0916-6678

Jeffrey Y ZhouDivision of General Internal Medicine, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-3683-3448

Manuel Carpio TumbaDivision of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-4199-2814

Tingyan HeAutoinflammatory Center of Excellence, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-0222-2091

Kader Cetin GedikAutoinflammatory Center of Excellence, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0003-1039-3701

Daniella M SchwartzDivision of Rheumatology and Clinical Immunology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.ORCID https://orcid.org/0000-0002-1660-8438

Funding

Molecular Basis of Pediatric DiseaseK12HD052892 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI TERENCE S. DERMODY · 2007 to 2026

$6.5M

NICHD NIH HHS K12 HD052892

6 · The paper itself

Abstract

Haploinsufficiency of A20 (HA20) is a primary immune regulation disease caused by heterozygous loss-of-function variants in

Identifiers

PMID42169681

DOI10.70962/jhi.20250138

PMCPMC13177427

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.