Evidence map›Paper›PMID 42169678›Full record

ArticleJournal of human immunity2026

Kawasaki disease complicated by macrophage activation syndrome treated with canakinumab.

Stejara A Netea, Diana van Stijn, Mariken P Gruppen, J Merlijn van den Berg, Nico A Blom, Irene M Kuipers, Taco W Kuijpers

Abstract read
In one paragraph

Article in Journal of human immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stejara A NeteaDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-3495-4705
Diana van StijnDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4179-9950
Mariken P GruppenDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-7698-1907
J Merlijn van den BergDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0001-9431-5457
Nico A BlomPediatric Cardiology, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-4823-6974
Irene M KuipersPediatric Cardiology, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0009-0006-1197-710X
Taco W KuijpersDepartment of Pediatric Immunology, Rheumatology and Infectious Diseases, Emma Children's Hospital, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.ORCID https://orcid.org/0000-0002-7421-3370

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An infant presented with macrophage activation syndrome as part of Kawasaki disease, and was first treated with canakinumab, followed by methylprednisolone and IVIG. Despite early treatment, giant coronary artery aneurysms developed transiently, questioning the singular role of IL-1 in KD.

Identifiers

PMID42169678
PMCPMC13177416

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.