Evidence map›Paper›PMID 42169571›Full record

ArticleAsian Pacific journal of cancer prevention : APJCP2026

Time to Treatment Initiation Analysis in Patients with Localized Extremity Non-Small Round Cell Sarcoma.

Sakurako Takahashi, Masatake Matsuoka, Tomohiro Onodera, Koji Iwasaki, Dai Sato, Taku Ebata, Yoshiaki Hosokawa, Eiji Kondo, Norimasa Iwasaki

Abstract read
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In one paragraph

Article in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sakurako TakahashiDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Masatake MatsuokaDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Tomohiro OnoderaDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Koji IwasakiDepartment of Functional Reconstruction for the Knee Joint, Hokkaido University, Kita-15, Nish-7, Kita-ku, Sapporo, Hokkaido, Japan.
Dai SatoDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Taku EbataDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Yoshiaki HosokawaDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.
Eiji KondoCentre for Sports Medicine, Hokkaido University Hospital, North 14 West 5, Kita-Ku, Sapporo, Hokkaido, Japan.
Norimasa IwasakiDepartment of Orthopaedic Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, North 15 West 7, Kita-Ku, Sapporo, Hokkaido, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTime-to-treatment initiation (TTI) is an increasingly recognized factor influencing survival in cancer care. Although prolonged TTI has been associated with worse survival in various malignancies, its impact on patients with localized extremity non-small-round-cell sarcoma (NSRCS) remains unclear.

methodsData were extracted from the SEER database, encompassing 11,380 patients diagnosed with localized extremity NSRCS from 2000 to 2019. Patients were categorized into three cohorts based on TTI: less than 1 month, less than 2 months, and less than 4 months. Kaplan-Meier survival analysis and Cox proportional hazards models were used to evaluate the association between TTI and overall survival (OS), adjusting for variables including age, sex, ethnicity, socioeconomic status, tumor location, AJCC stage, and treatment modalities.

resultsMultivariate analysis revealed that overall survival (OS) in the TTI delay group was nearly equivalent to that of patients with a TTI of less than 1 month (HR = 1.01; 95% confidence interval [CI], 0.97-1.10). In contrast, in cohorts 2 and 3, the TTI delay group demonstrated worse OS (cohort 2: HR = 1.10; 95% CI, 1.02-1.20; cohort 3: HR = 1.30; 95% CI, 1.10-1.70). Subgroup analysis indicated that adjuvant therapy, including chemotherapy and radiation therapy, may potentially mitigate the decreased survival associated with TTI delay. DISCUSSION: This study highlights the detrimental impact of delayed TTI on survival in patients with localized extremity NSRCS. Furthermore, it suggests that adjuvant therapy may help mitigate the adverse effects associated with TTI delay.

Indexed as

ExtremitiesSarcomaTime-to-TreatmentAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesSEER ProgramSurvival Rateneoplasm gradingretrospective studySEER programSoft tissue sarcomaTreatment outcome

Identifiers

PMID42169571

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.