Observational studyAsian Pacific journal of cancer prevention : APJCP2026
Comparative Analysis of Quality of Cell Collected from the Cervix: Conventional versus Liquid-Based Cytology.
Observational study in Asian Pacific journal of cancer prevention : APJCP, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo compare the qualitative and quantitative differences in several cell types between conventional cytology and liquid-based cytology samples in patients diagnosed with high-grade cervical intraepithelial neoplasia.
methodsA prospective, observational, cross-sectional study was conducted with 84 female patients at Santa Casa de Misericórdia de São Paulo Hospital (São Paulo, Brazil) between May 2019 and November 2020. Patients who underwent colposcopy-guided biopsy and were subsequently diagnosed with high-grade cervical intraepithelial neoplasia were included in this study. After the patients' selection, relevant information, conventional cytology, and liquid-based cytology samples were collected in the same session.
resultsLiquid-based cytology presented less neutrophilic infiltrate and a clean background, when compared to conventional cytology. We observed a larger amount of cell types (mature, basal, metaplastic, endocervical cells) in conventional cytology when compared to liquid-based cytology, with statistically significant results in all four cell types. We also observed a concordance rate of 90.6% in the cytological diagnosis between conventional and liquid-based cytologies.
conclusionEven though we found a greater amount of cells in conventional cytology, the diagnostic accuracy of both cytologies is similar. Therefore, in places in where conventional cytology is employed as the main screening method, a proper diagnosis is achieved.
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