ReviewJournal of the American Chemical Society2026
Strategic Applications of Single-Atom Skeletal Editing in Natural Product Synthesis.
Review in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Formal Chemoenzymatic Skeletal Editing of Fusicoccane Core to Access 6‑Aza-Fusicoccanes.JACS Au · 2026Article
- Direct Access to the SimplestJACS Au · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Skeletal editing is rapidly reshaping synthetic chemistry by enabling precise, atom-level modifications to complex molecular frameworks. Despite recent advances in methodology development, skeletal editing has yet to realize its full impact on complex molecule synthesis. In this Perspective, we highlight the power of single-atom skeletal editing transformations in enabling efficient syntheses of various complex natural products and advocate for the development of new methods and novel applications. We present guidelines rooted in historical precedent along with modern case studies that highlight when skeletal edits enable efficient synthesis, and where reactivity gaps still limit broader adoption. By analyzing the existing literature, we aim to inspire novel retrosynthetic disconnections, and steer new method development, which, collectively, will advance the fields of total synthesis and skeletal editing.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.