Evidence map›Paper›PMID 42169500›Full record

ArticleMolecular oncology2026

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr-mutated lung cancer.

Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya and 10 more

Abstract read
In one paragraph

Article in Molecular oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Jun NishimuraDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Tadahiro KuribayashiDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Johannes BrägelmannDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
Sachi OkawaDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Masataka TaokaDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Shunta MoriDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Tomoka NishimuraDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Takaaki TanakaDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Go MakimotoDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kiichiro NinomiyaCenter for Comprehensive Genomic Medicine, Okayama University Hospital, Japan.
Kammei RaiCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Eiki IchiharaCenter for Clinical Oncology, Okayama University Hospital, Japan.
Ryohei KatayamaDivision of Experimental Chemotherapy, Cancer Chemotherapy Centre, Japanese Foundation for Cancer Research, Tokyo, Japan.ORCID https://orcid.org/0000-0001-7394-895X
Katsuyuki HottaCenter for Innovative Clinical Medicine, Okayama University Hospital, Japan.
Masahiro TabataCenter for Clinical Oncology, Okayama University Hospital, Japan.
Yosuke TogashiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.ORCID https://orcid.org/0000-0001-9910-0164
Yoshinobu MaedaDepartment of Hematology, Oncology and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
Martin L SosDepartment of Translational Genomics, Faculty of Medicine and University Hospital Cologne, University of Cologne, Germany.
Katsuyuki KiuraDepartment of Respiratory Medicine, Okayama University Hospital, Japan.
Kadoaki OhashiDepartment of Respiratory Medicine, Okayama University Hospital, Japan.ORCID https://orcid.org/0000-0002-5180-3933

Funding

Deutsche Forschungsgemeinschaft CRC1310 project ID 325931972Deutsche Forschungsgemeinschaft CRC1399 project ID 413326622Japan Society for the Promotion of Science Challenging Research: 22K19529Japan Society for the Promotion of Science Scientific Research (B): KAKEN 19H03667Japan Society for the Promotion of Science Scientific Research (B): KAKEN 22H03078Japan Society for the Promotion of Science Scientific Research (B): KAKEN 24K02459Japan Society for the Promotion of Science Scientific Research (C): KAKEN 19K08625Ryobi Teien Memory FoundationSanyo Broadcasting Foundationthe CANTAR network Netzwerke 2021the German Cancer Aid [a Mildred Scheel Nachwuchszentrums] 70113307the German Cancer Aid [a Mildred Scheel Nachwuchszentrums] 70116929the German Ministry of Science and Education InCa grant ID: 01ZX1901the German Research Foundation GRK2338 (P13)the German Research Foundation SFB1399 (413326622)Wesco Science Foundation
6 · The paper itself

Abstract

Epidermal growth factor receptor (EGFR)-mutant non-small-cell lung cancers (NSCLCs) lack effective immunotherapy due to a noninflamed tumor microenvironment (TME). We previously reported that EGFR tyrosine-kinase-inhibitor (TKI) induced CD8

Indexed as

abscopal effectCD8+ T cellsEGFR mutationEGFR tyrosine kinase inhibitorNK cellsstimulator of interferon genes

Identifiers

PMID42169500
PMCPMC13398822

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.