SynthesisPsychiatry and clinical neurosciences2026
Effectiveness and safety of hyperbaric oxygen therapy for psychiatric disorders: A systematic review and meta-analysis.
Synthesis in Psychiatry and clinical neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Editorial: Hyperbaric oxygen therapy in psychiatry.Psychiatry and clinical neurosciences · 2026Article
- Aerospace stressors and brain health in military aviators: a glymphatic-neurovascular framework.Frontiers in physiology · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Psychiatric disorders such as major depressive disorder (MDD), posttraumatic stress disorder (PTSD), and anxiety are leading causes of disability and remain insufficiently treated in many patients. Hyperbaric oxygen therapy (HBOT), traditionally used in neurological care, has emerged as a potential intervention by delivering 100% oxygen at supra-atmospheric pressure to modulate neuroplasticity, inflammation, and cerebral perfusion. We conducted a systematic review and meta-analysis of studies evaluating HBOT in adults with psychiatric disorders across three databases. The prespecified primary endpoint was psychiatric symptom severity at treatment's end. Random-effects models were implemented in R (v4.4.0). Seventeen studies (n = 920) met inclusion criteria; nine randomized control trials (RCTs) contributed to the meta-analysis. For depressive symptoms, HBOT was associated with a large pooled effect (Cohen's d = -0.82; I
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