Evidence map›Paper›PMID 42169188›Full record

ArticleClinical epigenetics2026

Accelerated biological aging and underlying epigenetic modification mediated the association between obesity and asthma.

Jian Liu, Zhengqi Song, Chengge Shi, Xinan Lu, Aijun Zhang, Yihe Chen, Xuejia Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical epigenetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Jian Liu *The First Clinical Medical College, Wenzhou Medical University, Chashan, Wenzhou, 325000, Zhejiang, China.
Zhengqi Song *Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, 325000, Zhejiang, China.
Chengge Shi *The Second Affiliated Hospital, Yuying Children's Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, 325000, Zhejiang, China.
Xinan LuDepartment of Respiratory and Critical Care Medicine, Cixi People's Hospital, Wenzhou Medical University, Ningbo, 315000, Zhejiang, China.
Aijun ZhangDepartment of Respiratory and Critical Care Medicine, Cixi People's Hospital, Wenzhou Medical University, Ningbo, 315000, Zhejiang, China.
Yihe ChenDepartment of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang, Wenzhou, 325000, Zhejiang, China. chenyihe@wmu.edu.cn.
Xuejia ZhangDepartment of Respiratory and Critical Care Medicine, Cixi People's Hospital, Wenzhou Medical University, Ningbo, 315000, Zhejiang, China. xuejia891219@126.com.

Funding

Cixi City Public Welfare Special Project CN2024010Natural Science Foundation of China (NSFC) Grant No.81900229
6 · The paper itself

Abstract

backgroundThe relationships among obesity, accelerated biological aging, and asthma, as well as the underlying epigenetic mechanisms, remain incompletely understood.

methodsWe conducted a prospective cohort study in the UK Biobank to evaluate whether accelerated biological aging mediates the association between obesity and incident asthma. We then performed two-sample Mendelian randomization (MR) to assess the potential causal effect of accelerated biological aging on asthma from an epigenetic perspective. Epigenetic MR and colocalization analyses were used to prioritize aging-related DNA methylation (DNAm) CpG sites associated with asthma. Finally, single-cell RNA sequencing (scRNA-seq) was applied to characterize the cell-type-specific expression patterns of CpG-mapped genes.

resultsIn the UK Biobank cohort, KDM-BA acceleration and PhenoAge acceleration partially mediated the association between obesity and asthma, with proportions mediated of 4.0% and 12.2%, respectively. Two-sample MR further suggested that DNAm PhenoAge acceleration was associated with a higher risk of asthma (OR = 1.02; 95% CI: 1.01-1.03; P = 0.004). Epigenetic MR and colocalization analyses suggested that cg02010481 (JAZF1), cg17929770 (RSPH6A), cg19927816 (SYMPK; RSPH6A), cg08544331 (RUNX3), cg15498134 (RUNX3), and cg04389704 (FBXL19) were associated with a reduced risk of asthma, whereas cg16553500 (COL16A1), cg16351569, cg10036013 (FOXK1), cg11647481 (FOXK1), cg23776012 (KRT222), and cg08258403 were associated with an increased risk of asthma. In scRNA-seq analyses, JAZF1, SYMPK, FOXK1, and RUNX3 were differentially expressed across multiple immune cell types.

conclusionsThis study demonstrates that accelerated biological aging partially mediates the association of obesity with asthma and further elucidates underlying epigenetic mechanisms linking aging to asthma.

Indexed as

AgingAsthmaEpigenesis, GeneticObesityAgedCpG IslandsDNA MethylationFemaleHumansMaleMendelian Randomization AnalysisMiddle AgedProspective StudiesUnited KingdomasthmaBiological agingDNA methylationMendelian randomizationobesityprospective cohort

Identifiers

PMID42169188
PMCPMC13599159

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