Evidence map›Paper›PMID 42169149›Full record

ArticleJournal of translational medicine2026

Rel

Yuanqun Zhou, Yu Zhu, Yue Wu, Shunxin Yang, Xinming Xiang, Xingnan Ouyang, Qinghui Li, Xiaodan Wang, Li Wang, Liangming Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yuanqun Zhou *State Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yu Zhu *State Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Yue Wu *State Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Shunxin Yang, Department of Anesthesiology, University-Town Hospital of Chongqing Medical University, Chongqing 401331, China.
Xinming XiangState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Xingnan OuyangState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Qinghui LiState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Xiaodan WangState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China.
Li WangState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China. wangli123@tmmu.edu.cn.
Liangming LiuState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China. lmliu62@tmmu.edu.cn.
Tao LiState Key Laboratory of Trauma, Burns and Combined Injury, Shock and Transfusion Department, Daping Hospital, Army Medical University, Chongqing, 400042, China. lt200132@163.com.ORCID 0000-0002-9643-5185

Funding

China National Natural Science Foundation No. 82430082
6 · The paper itself

Abstract

backgroundCardiac dysfunction is a major cause of high mortality in sepsis. A well-organized cardiac microenvironment, consisting of cardiomyocytes and non-cardiomyocytes, is essential for maintaining heart function. The mechanism is still unclear.

methodsSingle-cell and single-nuclei RNA sequencing of the left ventricular tissues from cecal ligation and puncture-induced septic shock mice models were used to detect the change of cardiac cells. Immunofluorescence of myocardial tissue was conducted to validate key cell subpopulations, and PKM2 siRNA-loaded targeting nanomaterials were used to observe the role of Mac2.

resultsThe noncontractile phenotype of cardiomyocytes was major type following sepsis. Rel

conclusionsRel

Indexed as

Cellular MicroenvironmentMacrophagesMyocardiumSepsisAnimalsMaleMetabolic ReprogrammingMice, Inbred C57BLMyocytes, CardiacPhenotypeRNA, Small InterferingRNA, Small InterferingCardiac dysfunctionCardiac nicheCardiomyocyte contractileSepsis

Identifiers

PMID42169149
PMCPMC13483553

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.