Immunomodulatory piezoelectric master electrospun membranes for pelvic floor repair.

Xiaohan Fu, Haibo Chen, Wei Geng, Xiao Hou, Wenlan Xing, Min Cui, Xiumei Mo, Xiuyun Li

Abstract read

In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Xiaohan FuInfection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Haibo ChenDepartment of General Surgery, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Wei GengDepartment of Traditional Chinese Medicine, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Xiao HouDiagnosis and Treatment Center for Pelvic Floor Disease, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Wenlan XingInfection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Min CuiInfection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China.

Xiumei MoState Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine, College of Biological Science and Medical Engineering, Donghua University, Shanghai, 201620, P. R. China. xmm@dhu.edu.cn.

Xiuyun LiInfection and Microbiology Research Laboratory for Women and Children, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, 250014, P. R. China. lixiuyun666666@163.com.

Funding

Joint TCM Science & Technology Projects of National Demonstration Zones for Comprehensive TCM Reform GZY-KJS-SD-2023-064Research fund of China Maternal and Child Health Research Association 2023CAMCHS003A11Shandong Province Medical and Health Science and Technology Project 202525021132Shandong Provincial Maternal and Child Health Care Youth Scientific Innovation Project SFYZXJJ-2024021Shandong Provincial Medical and Health Science and Technology Project 202304101544Shandong Provincial Traditional Chinese Medicine Science and Technology Project Z20243207

6 · The paper itself

Abstract

Pelvic floor dysfunction (PFD) in women is characterized primarily by the functional degeneration of pelvic support structures, with pelvic organ prolapse (POP) being a common clinical manifestation. Current materials for repairing POP are limited by suboptimal mechanical performance and inadequate anti-inflammatory and antibacterial capabilities. Herein, a immunomodulatory piezoelectric master electrospun membrane is innovatively designed to provide integrated mechanical support, piezoelectric responsiveness, and immune microenvironment regulation. Electrospun membranes with uniformly loaded zinc oxide (ZnO) nanoparticles enabled the sustained release of Zn²⁺ for more than 20 days and achieved a piezoelectric coefficient (d

Indexed as

Immunologic FactorsPelvic FloorPelvic Organ ProlapseAnimalsAnti-Bacterial AgentsBiocompatible MaterialsCell AdhesionCell LineFemaleHumansInterleukin-10Interleukin-4Metal NanoparticlesMiceRatsRats, Sprague-DawleyAnti-Bacterial AgentsBiocompatible MaterialsImmunologic FactorsInterleukin-10Interleukin-4Zinc OxideElectrospunImmunomodulatoryPelvic organ prolapsePiezoelectric

Identifiers

PMID42169136

DOI10.1186/s12951-026-04582-0

PMCPMC13377707

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.