ArticleBMC research notes2026
WDFY4 gene polymorphisms (rs11101565 and rs2671702) are not associated with breast cancer risk in Bangladeshi women: a case-control study.
Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesBreast cancer is a complex malignancy influenced by both genetic and environmental mechanisms. The WDFY4 gene, predominantly expressed in immune tissues, plays a role in immune regulation. However, its application in relation to breast cancer risk among the Bangladeshi women has not been explored. The proposed case-control study was designed to determine the relationship between the susceptibility to breast cancer and the two WDFY4 polymorphisms, rs11101565 and rs2671702 and the association was evaluated by the T-ARMS-PCR method.
resultsFor rs11101565, the CA heterozygous genotype conferred a 1.36-fold increased risk compared to the CC wild-type genotype, though this association did not reach statistical significance (p > 0.05). Dominant and recessive models suggested elevated risk among AA homozygotes, while the overdominant model revealed a modest correlation; however, none achieved statistical significance. For rs2671702, the GA heterozygous genotype was associated with increased risk relative to GG, whereas the AA genotype exhibited a protective trend, yet all associations remained non-significant. Inconsistent risk patterns were observed across dominant and recessive models, while the minor allele A and overdominant model demonstrated stronger but statistically non-significant associations. Collectively, these findings indicate that WDFY4 polymorphisms (rs11101565 and rs2671702) do not significantly influence breast cancer susceptibility among Bangladeshi women.
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