ArticleBMC oral health2026
3D-embedding of human gingiva-derived mesenchymal stromal cells in "VitroGel
Article in BMC oral health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
6 authors.
Funding
Abstract
backgroundHuman gingiva-derived mesenchymal stromal cells (hG-MSCs) are promising candidates for cell-based therapy due to their immunomodulatory ability. Culturing in 3D hydrogels has emerged as a promising strategy to improve cell survival in the host and enhance clinical efficacy. This study assesses how embedding hG-MSCs in "VitroGel
methodshG-MSCs from six donors were either 3D-embedded in commercially available "VitroGel
resultsMetabolic activity was reduced in 3D-embedded hG-MSCs independently of the environment, but only in the presence of IFN-γ and TNF-α, a slight decrease in cell viability was observed. Hydrogel-embedded and -exposed hG-MSCs exhibited increased IL-8 expression under resting and IFN-γ conditions, and consistently upregulated COX-2 and PGE
conclusionsThese results demonstrate that 3D microenvironments reshape hG-MSC immunomodulatory potential, underscoring the relevance of 3D models for optimizing MSC-based therapies.
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