Evidence map›Paper›PMID 42168999›Full record

ArticleJournal of nanobiotechnology2026

A multimodal ROS generation and bimodal ferroptosis and cuproptosis self-reinforced strategy for effective bone metastases therapy.

Zhuo Ma, Qiao Ye, Xiaorui Song, Mengting Gao, Jinxuan Wang, Ximeng Zhang, Ziyi Wang, Ziliang Zheng, Ruiping Zhang

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhuo Ma *Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Qiao Ye *Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Xiaorui Song *Laboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Mengting GaoShanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Third Hospital of Shanxi Medical University, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Jinxuan WangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Ximeng ZhangThird Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, China.
Ziyi WangLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China.
Ziliang ZhengLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China. zzlsxty@sxmu.edu.cn.
Ruiping ZhangLaboratory of Molecular Imaging, Fifth Hospital of Shanxi Medical University (Shanxi Provincial People's Hospital), Taiyuan, 030000, China. zrp_7142@sxmu.edu.cn.

Funding

Ministry of Science and Technology of the People's Republic of China 2023YFC3402800National Natural Science Foundation of China 82120108016
6 · The paper itself

Abstract

Bone metastasis is a common complication in patients with advanced breast cancer, which can seriously damage the quality of life of patients and shorten their overall survival. About 70% of late patients will have bone metastasis, which often leads to serious bone-related events. In clinical practice, early and accurate diagnosis and treatment of bone metastasis are still major challenges. In this study, we have developed a new type of integrated nano diagnostic material (CuO

Indexed as

Bone NeoplasmsFerroptosisReactive Oxygen SpeciesAnimalsBreast NeoplasmsCell Line, TumorCuproptosisFemaleHumansMiceOxidative StressPhotoacoustic TechniquesPhotochemotherapyReactive Oxygen SpeciesBone metastasesCuproptosisFerroptosisNIR-IIPhotoacoustic imaging

Identifiers

PMID42168999
PMCPMC13637311

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.