Evidence map›Paper›PMID 42168976›Full record

ArticleBMC medicine2026

Disability free life expectancy: a simulation study of scenarios to extend healthy years and reduce inequalities.

David R Sinclair, Laurie E Davies, Barbara Hanratty, Chris Todd, Fiona E Matthews, Andrew Kingston

Abstract read
In one paragraph

Article in BMC medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

David R SinclairNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, Newcastle University, Newcastle upon Tyne, UK. David.R.Sinclair@newcastle.ac.uk.
Laurie E DaviesNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, Newcastle University, Newcastle upon Tyne, UK.
Barbara HanrattyNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, Newcastle University, Newcastle upon Tyne, UK.
Chris ToddNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, The University of Manchester, Manchester, UK.
Fiona E MatthewsNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, Newcastle University, Newcastle upon Tyne, UK.
Andrew KingstonNational Institute for Health and Care Research (NIHR) Policy Research Unit in Healthy Ageing, Newcastle University, Newcastle upon Tyne, UK.

Funding

Project-001R01AG017644 · NIA · UNIVERSITY OF LONDON INST OF NEUROLOGY · PI Andrew Steptoe · 2000 to 2026
$56.2M
National Institute for Health and Care Research NIHR206119NIA NIH HHS R01 AG017644
6 · The paper itself

Abstract

backgroundThe gap in Disability-Free Life Expectancy between affluent and deprived areas of England is stark, at over 15 years. Successive governments have recognised the need to narrow this and extend the years of life spent without disability, but there is little evidence outlining how large an intervention must be to achieve meaningful gains. This study examines intervention scenarios to (i) extend Disability-Free Life Expectancy and (ii) reduce socioeconomic inequalities in Disability-Free Life Expectancy, among older people in England.

methodsWe applied multistate modelling to longitudinal data on 16 899 individuals, aged 50 + in England, incorporating disability data from three cohort studies: the English Longitudinal Study of Ageing, the Cognitive Function and Ageing Study II, and the Newcastle 85 + Study. Simulations assessed how reducing the risk of disability associated with age and area-based socioeconomic deprivation could extend Disability-Free Life Expectancy. In these simulations, deprivation-targeted interventions reduced the excess disability risk and differential recovery observed in people living in the 20% most deprived areas. Age-targeted interventions reduced the age-related increase in disability risk and the corresponding decline in recovery.

resultsInterventions targeted solely at the most deprived quintile yielded modest Disability-Free Life Expectancy gains (up to 2.8 years for women and 2.3 years for men, in deprived areas only). Interventions targeting age-related disability risk alone were associated with increases in Disability-Free Life Expectancy of 6.3 to 8.7 years under a 40% reduction in age-related disability risk, but exacerbated the gap between the most and least deprived populations. Interventions addressing both age- and deprivation-associated risks demonstrated the greatest potential. A 30% decrease in the age-based probability of disability, and commensurate increases in recovery from disability, alongside removal of deprivation-associated inequalities, increased Disability-Free Life Expectancy by 4.8 to 8.6 years for men and women aged 50, with women living in deprived areas benefiting most.

conclusionsExtending Disability-Free Life Expectancy while reducing socioeconomic inequality is difficult, but possible by tackling both age- and deprivation-related risks. Taken on their own, age-based interventions risk increasing inequalities, as they disproportionately benefit people living in less deprived areas.

Indexed as

Healthy Life ExpectancyLife ExpectancyPersons with DisabilitiesAgedAged, 80 and overComputer SimulationEnglandFemaleHumansLongitudinal StudiesMaleMiddle AgedSocioeconomic Disparities in HealthSocioeconomic FactorsDeprivationDFLEHealth ExpectancyHealthy AgeingInequalitiesInterventionsMultistate modelPolicy

Identifiers

PMID42168976
PMCPMC13471628

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.