ArticleBMC endocrine disorders2026
Comparison of thyroid-specific quality of life after thermal ablation vs. thyroid lobectomy for benign thyroid nodules.
Article in BMC endocrine disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo compare the thyroid-specific quality of life (QoL) in patients with benign thyroid nodules (BTNs) who underwent thermal ablation (TA) versus thyroid lobectomy (TL).
methodsPatients with BTNs who underwent ultrasound-guided TA or TL were enrolled in the present study. The Thyroid Cancer-Specific Quality of Life Questionnaire (THYCA-QoL) which focus on thyroid-specific symptoms that are also relevant to patients with BTNs was used to evaluate patients' thyroid-specific QoL. Propensity score matching (PSM) was performed to control for confounding variables. Group differences in the THYCA-QoL scores were analyzed using t- tests.
resultsAfter PSM, 82 patients were included in each group. The median follow-up time for questionnaire administration was 3 (3, 3) months in the TA group and 6 (4, 8) months in the TL group. Compared with TL, the TA group reported significantly lower scores in voice, concentration, scar, tingling hands/feet, and weight gain (all p < 0.05), suggesting better thyroid-specific QoL. However, the TA group had higher scores on the "less interest in sex" scale, indicating more sexual interest-related concerns.
conclusionTA was associated with better thyroid-specific QoL than TL in several domains, though sexual interest-related concerns were slightly higher. These results suggest it may be a feasible alternative for patients with BTNs, with further studies needed to confirm long-term outcomes.
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