Evidence map›Paper›PMID 42168924›Full record

ArticleBMC ophthalmology2026

Impaired pupillary sensitivity in diabetic patients and correlation with visual outcome in cataract surgery.

Ye Li, Yuqi Xu, Qi Ren, Zeyu Pan, Fan Shi, Pengxia Wan

Abstract read
In one paragraph

Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Ye Li *Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Yuqi Xu *Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Qi Ren *Department of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Zeyu PanDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Fan ShiDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China.
Pengxia WanDepartment of Ophthalmology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, China. wanpengx@mail.sysu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province 2023A1515110031Medical Scientific Research Foundation of Guangdong Province, China A2024024
6 · The paper itself

Abstract

purposeTo investigate the relationship between pupillary response and diabetic characteristics in cataract patients and explore whether impaired pupillary function may impact cataract surgical outcomes and visual recovery in diabetic patients.

methodsThis prospective study included 362 participants (133 diabetic patients and 229 controls) who underwent cataract surgery. Diabetic patients were stratified by disease duration (≤ 1 year, 1-10 years, > 10 years). Pupil parameters and Visual quality metrics including higher-order aberrations (HOA), Strehl ratio (SR), and area ratio (AR) were evaluated using the OPD-Scan III aberrometer preoperatively and at 1 day, 1 week, and 1 month postoperatively.

resultsScotopic pupil diameter (PD) demonstrated a progressive decline with increasing diabetes duration. Patients with duration > 10 years showed significantly smaller scotopic pupils compared to controls (p < 0.0001) and shorter-duration subgroups (p < 0.01). PD difference deteriorated progressively in patients with duration > 1 year (p < 0.0001). Linear regression revealed that each 1% increase in HbA1c was associated with a 0.10 mm decrease in PD difference (β=-0.103, p < 0.001) and reduced scotopic PD (β=-0.112, p = 0.025). Postoperative visual quality parameters (HOA, SR, AR) showed comparable improvement between diabetic and control groups at all time points (p > 0.05), with diabetes duration showing minimal influence on outcomes.

conclusionDiabetic patients exhibit reduced pupillary sensitivity, particularly affecting scotopic pupil dilation, significantly associated with elevated HbA1c levels and longer diabetes duration. Postoperative improvements in visual quality of diabetic patients are comparable to those of non-diabetic patients, supporting use of functional intraocular lenses.

Indexed as

CataractCataract ExtractionPupilPupil DisordersVisual AcuityAgedFemaleHumansMaleMiddle AgedProspective StudiesCataractDiabetes mellitusPupil diameterPupillary sensitivityVisual quality

Identifiers

PMID42168924
PMCPMC13471384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.