ArticleBMC ophthalmology2026
Safety and pharmacokinetics of intravitreally repeatedly injected panitumumab in non-human primates - a study performed under good laboratory practice.
Article in BMC ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundEpidermal growth factor (EGF) has been suggested to play a role in myopic axial elongation, and EGF receptor blockade may be of potential therapeutic benefit. Here we examined the ocular and systemic toxicity of panitumumab, a clinically used EGF receptor blocker in oncology, when repeatedly administered intravitreally in non-human primates.
methodsThe experimental study included six non-human cynomolgus primates (3 males) which underwent five (n = 1 animal) or three (n = 5 animals) 4-weekly intravitreal injections of panitumumab (dose: 0.78 mg (78µL)) or of phosphate buffered solution (PBS) (78µL).
resultsThe study group with panitumumab injections consisted of 7 eyes and the control group with PBS injections of 5 eyes. Two animals of the study group developed on Day 59 (two days after the third injection) signs of a slight intraocular inflammation (cells in anterior chamber and vitreous) and reduction of intraocular pressure, with most of the signs having resolved at study end (Day 86). Panitumumab reached the serum peak concentration at 24 h after the first dose (C
conclusionsExcept for mild and reversible intraocular inflammation in some eyes, repeated intravitreal application of 0.78 mg panitumumab did not result in ophthalmological or systemic adverse effects in non-human primates.
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