ArticleBMC microbiology2026
Genomic characterization of an extensively drug-resistant Klebsiella pneumoniae co-harboring mcr-3.11, blaNDM-5 and blaCTX-M-27 isolated from pelvic effusion in a colon cancer patient.
Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveThis study aimed to characterize the genomic features and possible transmission mechanisms of an extensively drug-resistant (XDR) Klebsiella pneumoniae (KP2024). The isolate was recovered from pelvic effusion of a postoperative colon cancer patient in Hebei, China, with a focus on the rare mcr-3.11 gene as well as blaNDM-5 and blaCTX-M-27.
resultsGenetic analysis of key resistance determinants identified three epidemiologically important plasmids: an IncFIB plasmid carrying blaCTX-M-27 (pKP2024-1), an IncFII plasmid carrying mcr-3.11 (pKP2024-3), and an IncX3 plasmid carrying blaNDM-5 (pKP2024-4). Comparative genomic analysis indicated that blaCTX-M-27 was located within a highly conserved transposition unit mediated by ISEcp1. Additionally, mcr-3.11 and diacylglycerol kinase (dgkA) formed a conserved mobile genetic element, while blaNDM-5 was located within a typical Tn3-IS3000-IS5-blaNDM-5-bleMBL-trpF-IS26-ISKox3 structure on the IncX3 plasmid. All these plasmids harbored complete conjugative transfer systems or mobile genetic elements, indicating a high potential for horizontal gene transfer.
conclusionThis study reports an XDR K. pneumoniae co-harboring mcr-3.11, blaNDM-5, and blaCTX-M-27, isolated from the postoperative pelvic effusion of a colon cancer patient. Multiple key resistance genes are distributed on different types of plasmids, conferring resistance to "last-line" clinical agents such as carbapenems and colistin. The co-existence of multiple plasmids and the co-evolution of resistance genes may further increase the risk of resistance transmission, highlighting the importance of enhancing clinical surveillance for such highly resistant clones.
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