Evidence map›Paper›PMID 42168872›Full record

ArticleBMC microbiology2026

Antibacterial mechanism and in vivo efficacy of cladribine against carbapenem-resistant Klebsiella pneumoniae.

Kai-Di Liu, Fan-Yue Wang, Jun-Qi Liu, Wei-Hua Hao, Li-Li Guo, Yong-Da Zhao, Xiao-Ping Liao, Min-Ge Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Kai-Di LiuLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Fan-Yue WangLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Jun-Qi LiuLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Wei-Hua HaoLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China.
Li-Li GuoCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Yong-Da ZhaoCollege of Veterinary Medicine, Qingdao Agricultural University, Qingdao, China.
Xiao-Ping LiaoLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. xpliao@scau.edu.cn.
Min-Ge WangLaboratory of Veterinary Pharmacology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China. wangminge@lcu.edu.cn.

Funding

Development Program for Young Innovative Teams in Higher Education Institutions of Shandong Province 2024KJI019National Key Research and Development Program of China 2023YFD1800100National Natural Science Foundation of China 32202859
6 · The paper itself

Abstract

backgroundThe proliferation and dissemination of carbapenem-resistant Klebsiella pneumoniae (CRKP) constitutes a critical public health concern, underscoring the urgent need for novel antimicrobial agents. In this study, we identified cladribine, a synthetic purine analogue, as a potential antimicrobial candidate against CRKP.

resultsCladribine exhibited an MIC of 64 μg/mL against clinical CRKP isolates. Consistently, growth curve and time-kill assays also demonstrated that cladribine displays measurable inhibitory and bactericidal effects against CRKP, achieving a 4 log

conclusionThese findings suggest that cladribine has potential as a therapeutic candidate against CRKP infection and provide preliminary mechanistic insights that may contribute to a better understanding of its antibacterial activity.

Indexed as

Anti-Bacterial AgentsCarbapenem-Resistant EnterobacteriaceaeCladribineKlebsiella InfectionsKlebsiella pneumoniaeAnimalsCarbapenemsDisease Models, AnimalHumansMiceMicrobial Sensitivity TestsOxidative StressReactive Oxygen SpeciesAnti-Bacterial AgentsCarbapenemsCladribineReactive Oxygen SpeciesAntibacterial mechanismCladribineCRKPPulmonary infectionTherapeutic potential

Identifiers

PMID42168872
PMCPMC13371293

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.