Evidence map›Paper›PMID 42168772›Full record

ArticleChemistryOpen2026

Liquid Chromatography-Electrospray Ionization-Tandem Mass Spectrometry Profiling, Antioxidant, Antibacterial, and Antidiabetic Properties of Fagonia cretica L.: Insights From In Vitro and In Silico Approaches.

Neghmouche Nacer Salah, Elhafnaoui Lanez, Mohammed Larbi Benamor, Ouafa Zouari Ahmed, Yahia Bekkar, Moussa Senigra, Lazhar Bechki, Stefania Garzoli, Touhami Lanez

Abstract read
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In one paragraph

Article in ChemistryOpen, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Neghmouche Nacer SalahDepartment of Chemistry, Faculty of Exact Sciences, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Elhafnaoui LanezDepartment of Chemistry, Faculty of Exact Sciences, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Mohammed Larbi BenamorDepartment of Chemistry, Faculty of Exact Sciences, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Ouafa Zouari AhmedLaboratory of Biology, Environment, and Health, Faculty of Natural and Life Sciences, University of El-Oued, El-Oued, Algeria.
Yahia BekkarDepartment of Chemistry, Faculty of Exact Sciences, VTRS Laboratory, University of El Oued, El Oued, Algeria.
Moussa SenigraLaboratory of Applied Chemistry and Environment (LCAE), Chemistry Department, University of Hamma Lakhdar El Oued, El Oued, Algeria.
Lazhar BechkiDepartment of Chemistry, VPRS Laboratory, Faculty of Mathematics and Material Sciences, Kasdi Merbah University, Ouargla, Algeria.
Stefania GarzoliDepartment of Chemistry and Technologies of Drug, Sapienza University, Rome, Italy.ORCID 0000-0001-8535-0533
Touhami LanezDepartment of Chemistry, Faculty of Exact Sciences, VTRS Laboratory, University of El Oued, El Oued, Algeria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study provides an integrative evaluation of the aqueous extract of Fagonia cretica L., a species long employed in traditional medicine but insufficiently characterized through systematic experimental and computational approaches. The phytochemical profile, established by LC-ESI-MS/MS, revealed a predominance of phenolic acids (salicylic, ferulic, sinapic, gallic), flavonoids (quercetin, luteolin, apigenin, catechin, epicatechin), and the stilbene resveratrol. Quantitative assays confirmed a substantial phenolic load and flavonoid content. Biological investigations demonstrated that the extract exerted moderate yet consistent antioxidant capacity in DPPH, ABTS, CUPRAC, and ferric assays. Antibacterial activity was more selective, with pronounced inhibition against S. aureus and Micrococcus luteus, but negligible effect on E. coli. Inhibition of α-amylase was observed, indicating weak to modest metabolic benefits, though less potent than acarbose. In silico analyses reinforced these findings. ADMET predictions suggested favorable absorption and safety profiles for most constituents, with minimal risks of mutagenicity or carcinogenicity. Molecular docking identified quercetin, luteolin, and catechin as leading compounds, displaying strong binding affinities across antioxidant, antibacterial, and antidiabetic protein targets-at times surpassing reference ligands. Molecular dynamics simulations of representative complexes confirmed the stability of these interactions under physiological conditions.

Indexed as

Anti-Bacterial AgentsAntioxidantsHypoglycemic AgentsPlant ExtractsZygophyllaceaealpha-AmylasesChromatography, LiquidEscherichia coliFlavonoidsMicrobial Sensitivity TestsMicrococcus luteusMolecular Docking SimulationSpectrometry, Mass, Electrospray IonizationStaphylococcus aureusTandem Mass Spectrometryalpha-AmylasesAnti-Bacterial AgentsAntioxidantsFlavonoidsHypoglycemic AgentsPlant ExtractsbioactivitiesLC–ESI–MS/MSmolecular dockingmolecular dynamics simulationphenolic compounds

Identifiers

PMID42168772
PMCPMC13240333

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.