ReviewAdvances in experimental medicine and biology2026
Cell Fusion-Mediated Induction of Polyploidy, Aneuploidy, and Genomic Instability in Cancer Cells.
Review in Advances in experimental medicine and biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Cell fusion, which occurs in both tissue injury and cancer, inevitably results in polyploidization. While polyploid cells often fail to proliferate, polyploidization does not invariably lead to growth arrest, and polyploid cells can resume proliferation under certain conditions. Notably, the proliferation of polyploid cells is frequently accompanied by genomic instability, including replication stress and chromosomal instability. Furthermore, some polyploid cells have the capacity to reduce their ploidy and revert to a diploid state. Growing evidence indicates that such genomic instability and ploidy fluctuations act as driving forces of clonal evolution. This chapter discusses ploidy changes and genomic instability arising from cell fusion and examines how these alterations influence cellular behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.