ArticleMolecular neurobiology2026
Mild Cognitive Impairment Associated with Obstructive Sleep Apnoea: A Pilot Study on Oxygen-Related Plasma Biomarkers and Network Analysis.
Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Obstructive sleep apnoea syndrome (OSAS) is a breathing disorder frequently associated with mild cognitive impairment (MCI), a potential prodromal stage of Alzheimer's disease (AD). However, the mechanisms underlying MCI in OSAS remain unclear, making the identification of early biomarkers crucial. This pilot study investigates biochemical parameters related to oxygen disturbance and AD in OSAS patients with and without MCI (OSAS + MCI and OSAS-MCI, respectively) and explores their interplay through a network-based analysis. A total of 45 subjects (30 OSAS patients; 15 healthy controls) were enrolled, undergoing clinical assessment, polygraphy, and blood sampling. Compared to controls, OSAS patients exhibited increased apnoea-hypopnea index, oxygen desaturation index, and the percentage of cumulative time with oxygen saturation below 90% during total sleep time (T90). Notably, in the entire OSAS cohort, T90 positively correlated with HIF-1α levels, which were higher than controls, although not significantly. Interestingly, both T90 and HIF-1α were elevated in OSAS + MCI patients compared to OSAS-MCI, confirming a positive correlation between their levels. Regarding AD-related biomarkers, t-Tau and p-Tau
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