ArticleJournal of general internal medicine2026
Patient Preference Phenotypes for Post-operative Anticoagulation After Hip or Knee Replacement: A Cross-sectional Survey Study.
Article in Journal of general internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
objectivesPatients who receive hip or knee replacement surgery should be anticoagulated to prevent thrombosis-related events, such as pulmonary embolism. The Pulmonary Embolism Prevention after Hip and Knee Replacement (PEPPER) is a large pragmatic trial studying which anticoagulant (aspirin, warfarin, or rivaroxaban) is optimal. As an adjunct to this study, we examined the role of patients' preferences in the tailoring of therapy, focusing on identification of subgroups or preference phenotypes.
methodsWe constructed a multimedia conjoint analysis (CA) survey based on anticoagulants' beneficial and adverse effects at the expected probabilities being studied in the PEPPER trial. We recruited 192 hip and knee post-surgery patients at the Medical University of South Carolina who were eligible for the PEPPER trial and were studied 1 to 7 months after surgery. K-means clustering was used to characterize heterogeneity in patients' preferences.
resultsAcross the studied population, expected risks of major adverse effects (bleeding, venous thrombosis, and pulmonary embolism) were, on average, rated as being of similar importance, with somewhat greater weight being placed on avoiding risks of pulmonary embolism. However, few patients had values near the average for the population, with patients grouping in three distinct, minimally overlapping segments or preference phenotypes: thrombosis-focused values (aligns with rivaroxaban treatment), balanced values (bleeding and thrombosis-focus (aligns with aspirin)), and out-of-pocket-cost focused values (aligns with aspirin or warfarin).
conclusionsIn the post-knee/post-hip replacement setting, a CA survey revealed that patients value the risks and benefits of anticoagulation differently, with three distinct preference phenotypes that have potential implications for individualizing therapy.
Indexed as
Identifiers
42168707What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.