Evidence map›Paper›PMID 42168651›Full record

ArticleNature neuroscience2026

Foamy microglia link oxylipins to disease progression in multiple sclerosis.

Daan van der Vliet, Xinyu Di, Tatiana M Shamorkina, Claire Coulon-Bainier, Anto Pavlovic, Iris A C M van der Vliet, Yingyu Zeng, Will Macnair, Noëlle van Egmond, J Q Alida Chen and 16 more

Abstract read
In one paragraph

Article in Nature neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
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  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Daan van der VlietDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7317-9679
Xinyu DiDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
Tatiana M ShamorkinaBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-4191-6061
Claire Coulon-BainierPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Anto PavlovicPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Iris A C M van der VlietDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
Yingyu ZengDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0009-0008-8273-9699
Will MacnairPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.ORCID http://orcid.org/0000-0001-6357-0834
Noëlle van EgmondDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
J Q Alida ChenNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Aletta M R van den BoschNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0001-8886-8928
Hendrik J EngelenburgNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Dennis WeverNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.ORCID http://orcid.org/0000-0002-0801-4453
Matthew R J MasonNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands.
Wouter P F DrieverDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-9250-0381
Berend GagesteinDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
Elise DusseldorpMethodology and Statistics Unit, Institute of Psychology, Leiden University, Leiden, the Netherlands.
Marco van EijkDepartment of Bio-organic Synthesis, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands.
Uwe GretherPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.ORCID http://orcid.org/0000-0002-3164-9270
Netherlands Brain Bank
Amy C HarmsMetabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0002-2931-4295
Thomas HankemeierMetabolomics and Analytics Centre, Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands.ORCID http://orcid.org/0000-0001-7871-2073
Ludovic CollinPharma Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche, Basel, Switzerland.
Albert J R HeckBiomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, the Netherlands.ORCID http://orcid.org/0000-0002-2405-4404
Inge HuitingaNeuroimmunology Research Group, Netherlands Institute for Neuroscience, Amsterdam, the Netherlands. i.huitinga@nin.knaw.nl.ORCID http://orcid.org/0000-0002-4878-8920
Mario van der SteltDepartment of Molecular Physiology, Leiden Institute of Chemistry, Leiden University, Leiden, the Netherlands. m.van.der.stelt@chem.leidenuniv.nl.ORCID http://orcid.org/0000-0002-1029-5717

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek (Netherlands Organisation for Scientific Research) 184.034.019
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic neuroinflammatory disease in which demyelinating white matter lesions accumulate and expand, driving irreversible disability. Here we identify a distinct population of foamy GPNMB

Indexed as

Foam CellsMicrogliaMultiple SclerosisAnimalsDisease ProgressionFemaleHumansLipid MetabolismMacrophagesMaleMice

Identifiers

PMID42168651
PMCPMC13337515

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.