ArticleAnalytical and bioanalytical chemistry2026
Spatially resolved lipid compartmentalization in human pancreatic islets revealed by high-resolution ultra-low-flow-rate desorption electrospray ionization mass spectrometry imaging.
Article in Analytical and bioanalytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Human pancreatic islets are highly heterogeneous; thus, understanding their biological organization is crucial for elucidating metabolic function and diabetes pathogenesis. High-resolution mass spectrometry imaging of intact human pancreas is challenging due to the small size and dispersed distribution of individual islets within dense exocrine tissue. Here, we establish an ultra-low-flow-rate DESI mass spectrometry imaging (u-DESI-MSI) platform that enables lipidomic analysis of individual islets in human pancreatic tissue. Optimization of raster step size and scan rate parameters for u-DESI resulted in lipid ion images with enhanced spatial fidelity. The analysis demonstrates a highly reproducible central-peripheral spatial lipid distribution within pancreatic tissue. Diacyl phosphatidylcholines (diacyl-PCs), ether-linked phosphatidylcholines (ether-linked PCs) and sphingomyelins (SMs) are predominantly localized to the central endocrine region and co-register with intact insulin distributions, as further validated by matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). In contrast, specific lysophosphatidylcholines (LPCs) delineate the endocrine-exocrine interface. These results indicate the existence of position-dependent lipid organization within human islets. This platform provides a robust spatial-mapping foundation for future studies investigating structural and metabolic alterations in human islets under disease conditions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.