Evidence map›Paper›PMID 42168634›Full record

ArticleNature biomedical engineering2026

Human inflammatory bowel disease-on-a-chip for modelling disease progression, cancer initiation and sex-specific effects.

Alican Özkan, Gwenn E Merry, David B Chou, Ryan R Posey, Anna Stejskalova, Karina Calderon, Megan Sperry, Joshua Piatok, Viktor Horvath, Lorenzo E Ferri and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Frontiers in global women's health · 2026
    Review
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

18 authors.

Alican ÖzkanWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-3825-5899
Gwenn E MerryWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
David B ChouWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1659-9308
Ryan R PoseyWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Anna StejskalovaWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4813-6452
Karina CalderonWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Megan SperryWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Joshua PiatokWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Viktor HorvathWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0001-9957-1521
Lorenzo E FerriThoracic and Upper GI Cancer Research Laboratories, Research Institute of McGill University Health Centre, Montreal, Quebec, Canada.
Emanuela CarlottiClonal Dynamics in Epithelia Laboratory, Queen Mary University of London, London, UK.
Stuart A C McDonaldClonal Dynamics in Epithelia Laboratory, Queen Mary University of London, London, UK.ORCID http://orcid.org/0000-0002-2386-4915
Douglas J WintonCancer Research UK Cambridge Institute, Li Ka Shing Centre, Cambridge, UK.
Rocco RicciardiDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Liliana BordeianouDepartment of Surgery, Massachusetts General Hospital, Boston, MA, USA.
Sean HallWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.
Girija GoyalWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2163-2205
Donald E IngberWyss Institute for Biologically Inspired Engineering at Harvard University, Boston, MA, USA. don.ingber@wyss.harvard.edu.ORCID http://orcid.org/0000-0002-4319-6520

Funding

Cancer Research UK (CRUK) C19767/A27145U.S. Department of Health & Human Services | NIH | National Institute of Biomedical Imaging and Bioengineering (NIBIB) 5T32EB016652-10U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) 5T32DK007199-44Wyss Foundation Technology Development Fellowship
6 · The paper itself

Abstract

Patients affected by inflammatory bowel disease (IBD) exhibit compromised intestinal barrier function and decreased mucus accumulation, as well as increased inflammation, fibrosis and cancer risk, with symptoms often being exacerbated in women during pregnancy. Here we replicate these IBD hallmarks in human-derived organ-on-a-chip devices lined by colon epithelial cells from individuals with IBD when interfaced with matched fibroblasts, cultured under flow, exposed to peristalsis-like motions and perfused with circulating immune cells. Use of heterotypic tissue recombinants revealed that IBD fibroblasts are the primary drivers of multiple IBD symptoms. In the IBD chip, inflammation and fibrosis are accentuated by peristalsis-like motions and, in female-derived chips, also by exposure to pregnancy-associated hormones. When exposed to carcinogens, the IBD chip shows increased inflammation, gene mutations and chromosome duplication, in contrast to healthy chips. These data suggest that the intestinal stroma, sex hormones and peristalsis-associated mechanical deformations have a key role in driving inflammation, fibrosis and disease progression in male and female individuals with IBD.

Indexed as

Inflammatory Bowel DiseasesLab-On-A-Chip DevicesColonDisease ProgressionEpithelial CellsFemaleFibroblastsFibrosisGonadal Steroid HormonesHumansInflammationIntestinal Barrier FunctionIntestinal MucosaMaleMicrophysiological SystemsPeristalsisGonadal Steroid Hormones

Identifiers

PMID42168634
PMCPMC13672140

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.