Kinesiophobia, global health, pain, and bone mineral density in women with hypermobile Ehlers-Danlos syndrome: a prospective cohort study.

Anisha Vasireddi, Sara Strecker, Susan Giles

Abstract read

In one paragraph

Article in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Anisha VasireddiUniversity of Connecticut Medical School, Farmington, CT, USA.

Sara StreckerBone and Joint Institute, Hartford Hospital, 31 Seymour Street, Suite 202, Hartford, CT, 06106, USA. Sara.strecker@hhchealth.org.ORCID http://orcid.org/0000-0001-6425-2184

Susan GilesBone and Joint Institute, Hartford Hospital, 31 Seymour Street, Suite 202, Hartford, CT, 06106, USA.

Funding

Pastore Family Foundation Pastore Family Foundation

6 · The paper itself

Abstract

Hypermobile Ehlers-Danlos Syndrome (hEDS) is associated with joint hyperflexibility, pain, and connective tissue frailty. Patients are at high risk for fracture due to poor proprioception. This study reports on the mental and physical health, pain, physical activity, and kinesiophobia in patients with hEDS, and explores bone mineral density and fracture risk. This single-center, cross-sectional prospective study was approved by the IRB (HHC-2022-0143). Patients with diagnosed hEDS were consented and completed demographic forms, activity levels, PROMIS-10 Global Health Assessments, and the Tampa Kinesiophobia Scale, prior to DXA (Dual-energy X-ray absorptiometry) scans. Descriptive and inferential statistics were conducted including correlations and univariate regression analyses. All patients were female and pre-menopausal with a mean age of 36 (range: 19-55). Patients maintained an overall adequate bone mineral density (Spine: 1.16 ± 0.12 g/cm

Indexed as

Bone DensityEhlers-Danlos SyndromeJoint InstabilityKinesiophobiaAbsorptiometry, PhotonAdultCross-Sectional StudiesExerciseFemaleFractures, BoneHealth StatusHumansMiddle AgedProspective StudiesYoung AdultBone densityCongenital musculoskeletal diseasesConnective tissueEhlers-Danlos syndromeKinesiophobiaPain

Identifiers

PMID42168630

DOI10.1002/ajmg.a.63426

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.