ArticleNature2026
De novo design of miniproteins targeting GPCRs.
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In one paragraph
Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Programming biological behavior with AI-guided de novo protein design.Molecular cell · 2026Review
- Atomic, structural and molecular insights into GPCR ligand binding and signalling.Nature reviews. Molecular cell biology · 2026Review
- Sequence and structural determinants of efficacious de novo chimaeric antigen receptors.Nature biomedical engineering · 2026Article
- CD97/Cells · 2026Review
- Accelerating protein design by scaling experimental characterization.Nature communications · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
72 authors.
Edin Muratspahić *Department of Biochemistry, University of Washington, Seattle, WA, USA. edinm2@uw.edu.ORCID http://orcid.org/0000-0002-6011-0805
David Feldman *Department of Biochemistry, University of Washington, Seattle, WA, USA.
David E Kim *Department of Biochemistry, University of Washington, Seattle, WA, USA.
Xiangli Qu *Department of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-7556-7664
Ana-Maria Bratovianu *BioInnovation Institute, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9838-131X
Paula Rivera-Sánchez *BioInnovation Institute, Copenhagen, Denmark.
Jan Hendrik VossSkape Bio, Copenhagen, Denmark.
Emil P T HertzSkape Bio, Copenhagen, Denmark.ORCID http://orcid.org/0000-0001-6996-3559
Mads JeppesenSkape Bio, Copenhagen, Denmark.
Federica DimitriBioInnovation Institute, Copenhagen, Denmark.
Kensuke SakamotoDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0003-4488-1244
Amrita NallathambiSkape Bio, Copenhagen, Denmark.
Pia PeceliSkape Bio, Copenhagen, Denmark.
Jianjun CaoDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-9160-0228
Brian P CaryDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Matthew J BelousoffDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-3229-474X
Peter KeovDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-3829-6455
Phuc N H TrinhDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Qingchao ChenMRC Laboratory of Molecular Biology, Cambridge, UK.
Yue RenMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-2009-5348
Justyn FineProgram in Molecular Biophysics, Johns Hopkins University, Baltimore, MD, USA.
Sudha MishraDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Annu DalalDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Shachie SinhaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Ramanuj BanerjeeDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Manisankar GangulyDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.
Karthik Varappalayam KaruppusamyDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Isaac SappingtonDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Thomas SchlichthaerleDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Jason Z ZhangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-0091-6273
Arvind PillaiDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Brian CoventryDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-6910-6255
Ljubica MihaljevićDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Magnus S BauerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Susana Vázquez TorresDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Amir MotmaenDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4190-6215
Gyu Rie LeeDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-9119-5303
Long TranInstitute for Protein Design, University of Washington, Seattle, WA, USA.
Xinru WangDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-5994-707X
Inna GoreshnikDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Dionne K VafeadosDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0002-2560-8907
Justin E SvendsenDepartment of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.
Parisa HosseinzadehDepartment of Bioengineering, Knight Campus for Accelerating Scientific Impact, University of Oregon, Eugene, OR, USA.ORCID http://orcid.org/0000-0002-3128-7433
Nicolai LindegaardNovo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0009-0001-7024-0937
Matthäus BrandtNovo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0009-0002-6229-1328
Yann WaltenspühlNovo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0000-0001-5564-4303
Kristine DeiblerNovo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0000-0002-2376-8456
Lukas DeweidNovo Nordisk, Måløv, Denmark.
Anja BennettNovo Nordisk, Måløv, Denmark.
Jendrik SchöppeNovo Nordisk, Måløv, Denmark.ORCID http://orcid.org/0000-0002-2689-5549
Tiantang DongNovo Nordisk Research Centre China, Beijing, China.ORCID http://orcid.org/0009-0001-1668-0245
Xiaoli YanNovo Nordisk Research Centre China, Beijing, China.
Luke OostdykLeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA.ORCID http://orcid.org/0000-0001-9503-2168
William CaoLeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA.
Lakshmi AnantharamanLeadHunter Services, Eurofins DiscoverX, Fremont, CA, USA.
Johan J WeisserGlobal Research, H. Lundbeck, Copenhagen, Denmark.
Jesper Frank BastlundGlobal Research, H. Lundbeck, Copenhagen, Denmark.
Christoffer BundgaardGlobal Research, H. Lundbeck, Copenhagen, Denmark.ORCID http://orcid.org/0009-0009-5222-4499
Ayodeji A AsuniGlobal Research, H. Lundbeck, Copenhagen, Denmark.
Justin G EnglishDepartment of Biochemistry, University of Washington, Seattle, WA, USA.
Lance J StewartDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-4264-5125
Lauren HalloranTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.
Jamie B SpanglerTranslational Tissue Engineering Center, Johns Hopkins University, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-8187-3732
André LieberDepartment of Medicine, Division of Medical Genetics, University of Washington, Seattle, WA, USA.
Arun K ShuklaDepartment of Biological Sciences and Bioengineering, Indian Institute of Technology, Kanpur, India.ORCID http://orcid.org/0000-0003-2910-8288
Patrick M SextonDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-8902-2473
Bryan L RothDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0002-0561-6520
Brian E KrummDepartment of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID http://orcid.org/0000-0001-6039-4767
Denise WoottenDrug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-4563-1642
Christopher G TateMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-2008-9183
Christoffer NornDepartment of Biochemistry, University of Washington, Seattle, WA, USA. chris.norn@skape.bio.ORCID http://orcid.org/0000-0002-1450-4651
David BakerDepartment of Biochemistry, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7896-6217
Funding
In vivo HSC gene therapy using a multi-modular HDAd vector for HIV cureR01AI174304 · NIAID · UNIVERSITY OF WASHINGTON · PI HANS-PETER KIEM, ANDRE Michael LIEBER · 2023 to 2026
$4.3MSTRUCTURE AND FUNCTION OF MRG-FAMILY RECEPTORSR01DA055656 · NIDA · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bryan L. Roth, Brian K Shoichet · 2022 to 2026
$2.8MDesigned Vehicles for Blood Brain Barrier TraversalR01AG063845 · NIA · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.5MDesign of de novo interleukin mimics for targeted immunotherapyR01CA240339 · NCI · UNIVERSITY OF WASHINGTON · PI BAKER, DAVID · 2019 to 2023
$2.1MEngineered osteogenic growth factors for targeted stimulation of bone regenerationR21DE031436 · NIDCR · JOHNS HOPKINS UNIVERSITY · PI GRAYSON, WARREN L, SPANGLER, JAMIE BERTA · 2022 to 2023
$435kDe novo designed Ras tools to uncover the mechanisms underlying drug resistanceK99CA293001 · NCI · UNIVERSITY OF WASHINGTON · PI ZHANG, JASON · 2024 to 2024
$110kNCI NIH HHS K99 CA293001NCI NIH HHS R01 CA240339NIAID NIH HHS R01 AI174304NIA NIH HHS R01 AG063845NIDA NIH HHS R01 DA055656NIDCR NIH HHS R21 DE031436
Abstract
G-protein-coupled receptors (GPCRs) have key roles in physiology and are central targets for drug discovery and development
Indexed as
Cryoelectron MicroscopyDrug DesignReceptors, G-Protein-CoupledAnimalsHematopoietic Stem CellsHumansLigandsMiceModels, MolecularProtein BindingLigandsReceptors, G-Protein-Coupled
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.