Evidence map›Paper›PMID 42168556›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Duration of empiric antibiotic coverage for ruling out early-onset sepsis in neonates.

Tova Kruss, Mitzi Go, Dmitry Dukhovny, Angela Douglas

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tova KrussAffiliation with Oregon Health and Science University, Portland, OR, USA. tkruss@ohsu.edu.ORCID http://orcid.org/0009-0008-4082-8220
Mitzi GoAffiliation with Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0001-7098-3223
Dmitry DukhovnyAffiliation with Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0003-3327-2996
Angela DouglasAffiliation with Oregon Health and Science University, Portland, OR, USA.ORCID http://orcid.org/0000-0002-0800-5784

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionEarly-onset neonatal sepsis (EOS) carries significant mortality, prompting the initiation of empiric antibiotics pending blood culture results, which increases neonatal antibiotic exposure. In 2022, our institution shortened antibiotic coverage of EOS rule-outs from 36 to 24 h. We evaluated the safety of this change and its impact on antibiotic use.

methodsThis single hospital retrospective cohort study (2018-2023) compared infants <72 h of life who underwent EOS evaluation under 36- vs. 24-h protocols. Demographics, causative organisms, time to positivity (TTP), and antibiotic utilization for EOS were compared.

resultsAmong 1491 blood cultures, 17 had positive cultures and all had a TTP < 24 h. Cohorts were clinically similar. Mean antibiotic days initiated in the first 72 h of life decreased from 1.8 to 1.5 following the protocol change (Standard Deviations 0.29 and 0.25).

conclusionsReducing antibiotic coverage from 36 to 24 h lowered antibiotic exposure without inappropriate discontinuation of antibiotics.

Identifiers

PMID42168556

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.