ArticlePediatric research2026
Point of care and plasma glucose measurements in the newborn: agreement and precision.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPoint-of-care (POC) devices for glucose measurement provide rapid results, but the accuracy of the measurement compared with the reference standard (laboratory-based plasma testing) in newborns is unclear.
methodsWe evaluated the agreement of paired POC (StatStrip glucometer) and plasma glucose measurement using the Bland-Altman method for repeated measures. Limits of agreement (LOA) falling within ±15 mg/dL were determined a priori to be acceptable.
resultsWe analyzed 4071 paired POC and laboratory-based glucose measurements from 2065 unique patients; (mean ± SD) gestational age of 33.1 ± 5.6 weeks and birth weight of 2216.2 ± 1186.0 g. When accounting for repeated measures, the estimated mean bias was 0.86 mg/dL (95% CI: 0.40, 1.32) with LOA -61.77 to 63.49 mg/dL (95% CI: -62.91, 64.63), beyond the acceptable ±15 mg/dL. If the POC method was used alone, 7.7% of hypoglycemia and 8.2% of hyperglycemia would be undertreated. Conversely, 3.6% of euglycemia would be overtreated for hypoglycemia, and 1% overtreated for hyperglycemia.
conclusionPOC glucose measurements using the StatStrip glucometer showed poor precision with a greater tendency for undertreatment than overtreatment. Clinicians should be cognizant of this while interpreting bedside POC glucose measurements. IMPACT: Glucose point-of-care measurements in a newborn population showed poor precision and should not be considered interchangeable with the plasma measurements.
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