Targeting the outer membrane porin OprF restores carbapenem efficacy during experimental sepsis caused by NDM-1-producing Pseudomonas aeruginosa.

S Herrera-Espejo, J Findlay, J M Cisneros, María Eugenia Pachón-Ibáñez, P Nordmann

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

S Herrera-Espejo *Department of Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

J Findlay *Department of Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

J M CisnerosInstitute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, CSIC/University of Seville, Sevilla, Spain.

María Eugenia Pachón-IbáñezInstitute of Biomedicine of Seville (IBiS), Virgen del Rocio University Hospital, CSIC/University of Seville, Sevilla, Spain. mpachon-ibis@us.es.

P NordmannDepartment of Medical and Molecular Microbiology, Faculty of Science and Medicine, University of Fribourg, Fribourg, Switzerland.

Funding

Instituto de Salud Carlos III CB21/13/00006Servicio Andaluz de Salud RC1-0006-2023

6 · The paper itself

Abstract

Carbapenem resistance in Pseudomonas aeruginosa may depend on both carbapenemase production and outer membrane porin composition. Disruption of the major porin OprF altered motility and secretion system gene expression without reducing virulence, and restored imipenem efficacy in an NDM-1-producing strain in a murine sepsis model. To the best of our knowledge, a dual role of inhibition of pathogenicity and overcoming antibiotic resistance by disrupting a membrane protein, is novel.

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsPorinsPseudomonas aeruginosaPseudomonas InfectionsSepsisAnimalsDisease Models, AnimalImipenemMiceAnti-Bacterial AgentsBacterial Proteinsbeta-lactamase NDM-1beta-LactamasesCarbapenemsImipenemOprF protein, Pseudomonas aeruginosaPorinsCarbapenemase-producing Pseudomonas aeruginosaImipenemOprF

Identifiers

PMID42168482

DOI10.1038/s41598-026-53218-8

PMCPMC13503651

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.