ArticleFunctional & integrative genomics2026
The m6A reader IGF2BP3 promotes triple-negative breast cancer metastasis through HOXB9-IL15RA pathway.
Article in Functional & integrative genomics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Triple-negative breast cancer (TNBC) is among the most life-threatening women malignancies with largely uncharacterized pathogenic mechanisms. While N6-methyladenosine (m6A) methylation has been documented to impact carcinogenesis through extensively altering the gene expression profile, its precise role in TNBC remains poorly understood. Here, we found that insulin-like growth factor 2 mRNA-binding protein 3 (IGF2BP3) promotes TNBC progression in an m6A modification-dependent way. Mechanistically, IGF2BP3 binds to and stabilizes the mRNA of a transcription factor, HOXB9, which subsequently licenses the expression of interleukin 15 receptor α subunit (IL-15RA). The IL-15/IL15RA signaling thus potentiates the migration and invasion of neoplastic cells and contributes to in vivo metastasis of TNBC. These observations provide novel insights into the role of RNA modification in the occurrence of TNBC, and demonstrate the applicability of targeting the m6A machinery especially specific reader proteins in the clinical treatment of advanced TNBC.
Indexed as
Identifiers
42168464What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.