ReviewCalcified tissue international2026
Role of YAP/TAZ Mechanobiological Signaling in Osteoporosis and Osteoarthritis.
Review in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Peroxisome proliferator-activated receptor gamma (PPARγ) as a mechano-metabolic transducer: coordinating lipid homeostasis through mechanical cues.Molecular biomedicine · 2026Review
- Integrated bioinformatic and experimental analyses identify Lumican as a key regulator of LIPUS-induced osteogenesis through Integrin β1/FAK/ERK signaling.Molecular biology reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Osteoporosis and osteoarthritis are prevalent degenerative bone diseases characterized by the deterioration of bone structure and function. Mechanical signals play a crucial role in their pathogenesis by modulating cellular behavior and tissue homeostasis. Yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ), key transcriptional regulators of the Hippo pathway, act as critical mechanosensors that translate mechanical cues into osteocyte and chondrocyte responses. Specifically, YAP/TAZ regulate osteocyte lacunar-canalicular remodeling, chondrocyte mechanoadaptation, and extracellular matrix metabolism, driving bone and cartilage degeneration when dysregulated. Historically, the Hippo pathway was initially linked to organ size control, but recent advances highlight its central role in skeletal mechanobiology. This narrative review elucidates YAP/TAZ-mediated mechanobiological signaling in osteoporosis and osteoarthritis, examining their roles in osteocyte differentiation, apoptosis, and tissue repair. We analyze associated molecular networks and aberrant expressions in disease, emphasizing the therapeutic potential of targeting YAP/TAZ for stage-specific interventions, such as promoting bone formation or inhibiting cartilage breakdown.
Indexed as
Identifiers
42168415What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.