Evidence map›Paper›PMID 42168396›Full record

ReviewJournal of molecular medicine (Berlin, Germany)2026

The mechanism of the JNK signaling pathway in drug addiction : Author list.

Shuang Han, Hongming Ye, Min Li, Yuzhu Wang, Yue Chen, Xiaohong Zhou, Zicheng Li

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of molecular medicine (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Shuang Han *The First College of Clinical Medical Science, China Three Gorges University, Yichang Central People's Hospital, Yichang, 443000, China.
Hongming Ye *Hubei Polytechnic Institute, Xiaogan, 432000, China.
Min Li *Hubei Province Clinical Medical Research Center for Rare Diseases of Nervous System, Yichang, 443000, China.
Yuzhu Wang *College of Basic Medical Sciences, China Three Gorges University, Yichang, China.
Yue ChenCollege of Medicine, Jiaxing University, Jiaxing, 314001, People's Republic of China.
Xiaohong ZhouCollege of Basic Medical Sciences, China Three Gorges University, Yichang, China.
Zicheng LiCollege of Basic Medical Sciences, China Three Gorges University, Yichang, China. zichengli@ctgu.edu.cn.ORCID http://orcid.org/0000-0001-8533-5325

Funding

Guiding Project of Scientific and Technological Research Plan of Hubei Provincial Department of Education B2024536Hubei Provincial Natural Science Foundation of China 2021CFB232Hubei Provincial Natural Science Foundation of China-Yichang Innovation and Development Joint Fund Project 2025AFD276
6 · The paper itself

Abstract

Drug addiction is a multifactorial neurofunctional disorder influenced by a complex interplay of environmental, biological, and genetic factors. Recent studies have demonstrated that aberrant activation of the c-Jun N-terminal kinase (JNK) signaling pathway plays a critical role in the development of drug addiction. JNK, a member of the mitogen-activated protein kinase (MAPK) family, participates in neural development during embryogenesis and regulates neuronal proliferation and differentiation in adulthood, thereby maintaining the functional integrity of neural stem and progenitor cells and preserving appropriate brain plasticity and homeostasis. By modulating key biological processes such as inflammation, oxidative stress, autophagy, and apoptosis, the JNK signaling pathway regulates neuronal homeostasis and synaptic plasticity and contributes to the molecular mechanisms underlying drug addiction. In addition, JNK signaling influences addiction-related epigenetic regulation by modulating DNA methylation. This review comprehensively analyzes the involvement of the JNK signaling pathway in drug addiction, to broaden current perspectives on addiction research and inform the development of novel therapeutic strategies.

Indexed as

JNK Mitogen-Activated Protein KinasesMAP Kinase Signaling SystemSubstance-Related DisordersAnimalsAutophagyEpigenesis, GeneticHumansOxidative StressJNK Mitogen-Activated Protein KinasesApoptosis and autophagyDrug addictionEpigeneticsInflammationJNK signaling pathwayOxidative stress

Identifiers

PMID42168396

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.