Evidence map›Paper›PMID 42168306›Full record

ArticleScientific reports2026

Patient-friendly simplification and translation of neuroradiology impressions using artificial intelligence.

Wendy Sun, Advait Patil, Maria A Vicent, Basile Montagnese, John Zielke, Gerald M Hefferman, Ian Pan, Gracie Cleaver, Mark C Eldaief, Rajesh Patel and 7 more

Abstract read
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Wendy SunDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Advait PatilDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Maria A VicentDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Basile MontagneseDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
John ZielkeDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Gerald M HeffermanDepartment of Radiology, Mass General Brigham, Boston, MA, USA.
Ian PanDepartment of Radiology, Mass General Brigham, Boston, MA, USA.
Gracie CleaverDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Mark C EldaiefDepartment of Neurology, Mass General Brigham, Boston, MA, USA.
Rajesh PatelDepartment of Medicine, Mass General Brigham, Boston, MA, USA.
Daniela L Mendoza-MillanDepartment of Dermatology, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Julia LandryGeorgetown University School of Medicine, Washington, DC, USA.
Oscar Moreno-LizarazoHarvard Medical School, Boston, MA, USA.
O Angel OdukoyaDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Benjamin R JohnstonDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Kevin T HuangDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA.
Omar ArnaoutDepartment of Neurosurgery, Mass General Brigham, Boston, MA, USA. oarnaout@bwh.harvard.edu.

Funding

Medical Scientist Training ProgramT32GM007753 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WALENSKY, LOREN DAVID · 1985 to 2021
$50.0M
Medical Scientist Training ProgramT32GM144273 · NIGMS · HARVARD MEDICAL SCHOOL · PI David Shumway Jones, Jacqueline A. Lees · 2022 to 2026
$14.7M
MD-PhD Training Program in Aging and the Social/Behavioral SciencesT32AG051108 · NIA · HARVARD MEDICAL SCHOOL · PI MCWILLIAMS, JOHN MICHAEL · 2015 to 2025
$2.1M
NIA NIH HHS T32 AG051108NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIH HHS T32AG51108NIH HHS T32GM007753
6 · The paper itself

Abstract

Healthcare systems in the United States are now mandated to provide patients with immediate access to medical results. Access to complex results prior to appropriate clinical follow-up may cause confusion and fear, especially in populations with limited health literacy and English language proficiency. In this study, we demonstrate a use case of large language models (LLMs) to simplify and translate complex medical information for patients. We collected a consecutive series of brain MRI (N = 200), head CT (N = 100), and spine MRI (N = 200) reports, prompting a GPT-4o model to simplify these reports to a middle-school reading level and translate a subset of them to Spanish. Critically, two independent neuroradiology raters compared the simplified report impressions to the original report impressions, and found low rates of hallucinations, omissions, and imprecisions. The reading grade of the report impressions decreased from approximately college to approximately middle-school level, and readability improved across several text complexity metrics. Additionally, simplified impressions were classified as more neutral and less fearful. Machine generated translations of simplified impressions were statistically indistinguishable from manual translations as assessed by certified interpreters. In sum, we present a scalable, patient-friendly approach to promote healthcare literacy and engagement.

Indexed as

Artificial IntelligenceNeuroimagingTranslatingFemaleGenerative Artificial IntelligenceHumansLarge Language ModelsMagnetic Resonance ImagingMalePlain Language Summaries

Identifiers

PMID42168306
PMCPMC13396350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.