SynthesisScientific reports2026
Endovascular thrombectomy with or without intravenous thrombolysis in large-vessel ischemic stroke: an updated meta-analysis.
Synthesis in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Guidelines continue to recommend intravenous thrombolysis before endovascular thrombectomy for acute ischemic stroke due to large-vessel occlusion. Its added benefit remains debated. This meta-analysis investigated whether bridging therapy with systemic thrombolytics improves functional independence compared with thrombectomy treatment alone. A systematic search of randomized controlled trials comparing intravenous thrombolysis plus endovascular treatment versus endovascular thrombectomy alone was conducted. We searched PubMed, Embase, Web of Science, Cochrane Library, and medRxiv to June 3, 2025. Search terms included "stroke", "thrombectomy", and "thrombolysis" and synonyms. The primary efficacy outcome was functional independence at 90 days, defined as a modified Rankin scale (mRS) score of 0 to 2. Random-effects models with inverse-variance weighting were used to calculate pooled risk ratios. Heterogeneity was quantified by Chi-square and I
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.