Evidence map›Paper›PMID 42168238›Full record

ArticleNPJ microgravity2026

A novel mineral-organic bone adhesive promotes calvarial bone regeneration in microgravity conditions.

Roberta Di Carlo, Uzma Mhate, Luigi Mancinelli, Sourabh Boruah, Taiana C Leite, Xuehui Geng, Michael C Brown, Afton K Limberg, Douglas W Van Citters, Brian J Hess and 2 more

Abstract read
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In one paragraph

Article in NPJ microgravity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Roberta Di CarloDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Uzma MhateRevBio, Inc., Lowell, MA, USA.
Luigi MancinelliDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Sourabh BoruahRevBio, Inc., Lowell, MA, USA.
Taiana C LeiteDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Xuehui GengDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Michael C BrownRevBio, Inc., Lowell, MA, USA.
Afton K LimbergThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Douglas W Van CittersThayer School of Engineering, Dartmouth College, Hanover, NH, USA.
Brian J HessRevBio, Inc., Lowell, MA, USA.
George W KayRevBio, Inc., Lowell, MA, USA.
Giuseppe IntiniDepartment of Periodontics and Preventive Dentistry, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA, USA. gii5@pitt.edu.

Funding

Center for the Advancement of Science in Space GA-2020-0983
6 · The paper itself

Abstract

Microgravity significantly impacts astronaut physiology, causing accelerated bone loss and impairing bone regeneration. As human space exploration expands, effective and minimally invasive bone repair treatments are crucial. In this study, we investigated the regenerative potential of a novel mineral-organic bone adhesive, Tetranite® (TN), compared to the osteoinductive rhBMP2 (Infuse®). We used a critical-size calvarial bone defect model in mice, with half launched on a 60-day mission to the International Space Station and the other half serving as ground controls. Histological and quantitative micro-computed tomography (MicroCT) analyses confirmed that both TN and rhBMP2 promoted bone regeneration in both spaceflight and ground conditions. While both biomaterials were effective, TN's regenerative effect was more localized to the defect site. Our findings demonstrate that TN implantation effectively promotes calvarial bone regeneration under both microgravity and terrestrial conditions. This suggests its potential as a minimally invasive clinical solution for treating bone fractures during future space missions and on Earth.

Identifiers

PMID42168238
PMCPMC13462544

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.