Evidence map›Paper›PMID 42168230›Full record

ArticleNature communications2026

Structural basis and physiological significance of non-canonical G

Atsuro Oishi, Hiroyuki H Okamoto, Keisuke Ikegami, Ronan McHugh, Bernard Masri, Tsukasa Kusakizako, Kazuhiro Kobayashi, Akifumi Takaki, Angeliki Karamitri, Erika Cecon and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Atsuro Oishi *Université Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. aoishi@ks.kyorin-u.ac.jp.ORCID http://orcid.org/0000-0003-1788-5485
Hiroyuki H Okamoto *Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.
Keisuke Ikegami *Department of Physiology, School of Medicine, Aichi Medical University, Nagakute, Aichi, Japan.ORCID http://orcid.org/0000-0001-5606-3965
Ronan McHughSchool of Pharmacy, Queen's University Belfast, Belfast, UK.
Bernard MasriUniversité Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.ORCID http://orcid.org/0000-0002-4027-2604
Tsukasa KusakizakoDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-6186-6647
Kazuhiro KobayashiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan.ORCID http://orcid.org/0000-0002-3366-3586
Akifumi TakakiLaboratory of Regulation in Metabolism and Behavior, Faculty of Agriculture, Kyushu University, Fukuoka, Japan.
Angeliki KaramitriUniversité Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.
Erika CeconUniversité Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.ORCID http://orcid.org/0000-0003-2387-9313
Julie DamUniversité Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France.ORCID http://orcid.org/0000-0001-6871-2678
Miki NagaseDepartment of Anatomy, Kyorin University School of Medicine, Mitaka, Tokyo, Japan.
Irina G TikhonovaSchool of Pharmacy, Queen's University Belfast, Belfast, UK.ORCID http://orcid.org/0000-0002-6228-9431
Osamu NurekiDepartment of Biological Sciences, Graduate School of Science, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. nureki@bs.s.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0003-1813-7008
Ralf JockersUniversité Paris Cité, Institut Cochin, INSERM, CNRS, 75014, Paris, France. ralf.jockers@inserm.fr.ORCID http://orcid.org/0000-0002-4354-1750

Funding

Agence Nationale de la Recherche (French National Research Agency) ANR-23-CE14-0033Fondation pour la Recherche Médicale (Foundation for Medical Research in France) Equipe FRM DEQ.20130326503Japan Agency for Medical Research and Development (AMED) JP233fa627001Japan Agency for Medical Research and Development (AMED) JP25am121002 (support no. 3272), JP25ama121012MEXT | Japan Science and Technology Agency (JST) (FOREST) JPMJFR215UMEXT | Japan Science and Technology Agency (JST) JPMJCR20E2MEXT | Japan Society for the Promotion of Science (JSPS) 21H05037MEXT | Japan Society for the Promotion of Science (JSPS) 21J20897MEXT | Japan Society for the Promotion of Science (JSPS) 22K06132, 25K10187MEXT | Japan Society for the Promotion of Science (JSPS) Grant Number 19K09962RCUK | Biotechnology and Biological Sciences Research Council (BBSRC) BB/R007101/1RCUK | Engineering and Physical Sciences Research Council (EPSRC) EP/T022175/1 and EP/W03204X/1
6 · The paper itself

Abstract

G protein-coupled receptors (GPCRs) transduce extracellular stimuli into intracellular signals by coupling to various heterotrimeric G proteins. However, the rules governing G protein preference remain largely elusive. MT

Indexed as

GTP-Binding Protein alpha Subunits, GsReceptor, Melatonin, MT1AnimalsCryoelectron MicroscopyCyclic AMPHEK293 CellsHumansMelatoninModels, MolecularProtein BindingReceptor, Melatonin, MT2Cyclic AMPGTP-Binding Protein alpha Subunits, GsMelatoninReceptor, Melatonin, MT1Receptor, Melatonin, MT2

Identifiers

PMID42168230
PMCPMC13385403

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.