ArticleNature communications2026
Total syntheses of (+)-dalesconols A and B enabled by triple-relayed remote chirality transfer.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Dalesconols A and B, featuring unique and highly congested polycyclic carbon frameworks and notable biological activities, have attracted sustained attention. However, their structural complexity constitutes a significant challenge for total synthesis. Herein, we present the asymmetric total syntheses of (+)-dalesconols A and B via a remote chirality transfer strategy. Central to this approach is the implementation of our palladium/norbornene-catalyzed trifunctionalization method, which enables one-step construction of the chiral polycyclic core skeleton via a triple relay of point-to-axial, axial-to-axial, and axial-to-point chirality transfer. Combined with intramolecular Michael addition, C-H oxidation/retro-Michael elimination, and global demethylation, this triple-relayed remote chirality transfer strategy allows concise and modular access to (+)-dalesconols A and B.
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