ArticleNature communications2026
Real-time volumetric imaging of cells and molecules in deep tissues with Takoyaki ultrasound.
Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Trimodal ultrasound imaging of brain-tumor interaction.iScience · 2026Article
- High-Volume Acquisition Rate Nonlinear Imaging Enables Robust 3-D Ultrasound Localization Microscopy.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2025Article
- Probiotic acoustic biosensors for noninvasive imaging of gut inflammation.Nature communications · 2025Article
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5 authors.
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Abstract
Acoustic contrast agents and reporter genes play a critical role in allowing ultrasound to visualize blood flow, map molecules and track cellular function in optically opaque living organisms. However, many advanced agents requiring high acoustic pressures have been imaged primarily in 2D, while biological phenomena of interest unfurl in three dimensions. Here, we introduce a method for efficient, dynamic imaging of contrast agents and reporter genes in 3D using multiplexed matrix array transducers. Our "Takoyaki" pulse sequence uses the simultaneous scanning of multiple focal points to excite contrast agents with sufficient acoustic pressure for nonlinear imaging while efficiently covering 3D space. We first characterize and benchmark Takoyaki imaging performance with gas vesicle contrast agents in vitro. Then we establish utility in cellular imaging by visualizing acoustic reporter gene expression in a mouse model of glioblastoma. Finally, we demonstrate real-time volumetric imaging by tracking the dynamics of fluid motion in mouse brain ventricles during and after intraventricular contrast injection. Takoyaki imaging enables a more comprehensive understanding of biological processes by providing spatiotemporal information in 3D within the constraints of accessible multiplexed matrix-array systems.
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