Evidence map›Paper›PMID 42168197›Full record

ArticleNature communications2026

Molecular basis of allosteric regulation and pharmaceutical targeting of protein kinase Cβ.

Anh T Q Cong, Taylor L Witter, Elizabeth S Bruinsma, Sayantani Sarkar Bhattacharya, Swaathi Jayaraman, Samuel R Wyatt, Jasper K Solverson, Maria B Dugan, Jasmina Paluncic, Mary J Kuffel and 8 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Anh T Q Cong *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9307-7741
Taylor L Witter *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3096-3011
Elizabeth S Bruinsma *Department of Oncology, Mayo Clinic, Rochester, MN, USA.
Sayantani Sarkar Bhattacharya *Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-8971-7566
Swaathi Jayaraman *Department of Oncology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0002-5451-0052
Samuel R WyattDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.
Jasper K SolversonDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5801-821X
Maria B DuganDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-5862-6637
Jasmina PaluncicDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3420-1532
Mary J KuffelDepartment of Oncology, Mayo Clinic, Rochester, MN, USA.
Julia R AlveyDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-6549-9816
Huy V HuynhDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0009-0007-9304-8087
Xinyan WuDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.
Alan P FieldsDepartment of Cancer Biology, Mayo Clinic, Jacksonville, FL, USA.ORCID http://orcid.org/0000-0001-9529-0888
Akhilesh PandeyDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-9943-6127
John R HawseDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0003-3406-470X
Matthew P GoetzDepartment of Oncology, Mayo Clinic, Rochester, MN, USA. goetz.matthew@mayo.edu.ORCID http://orcid.org/0000-0002-4383-270X
Matthew J SchellenbergDepartment of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN, USA. schellenberg.matthew@mayo.edu.ORCID http://orcid.org/0000-0001-7036-5943

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
The Role of CHFR in Tumorigenesis and Paclitaxel-Sensitivity in Breast CancerP50CA116201 · NCI · MAYO CLINIC ROCHESTER · PI PETER C LUCAS · 2005 to 2026
$49.9M
User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI STEVEN E EALICK · 2018 to 2026
$34.2M
User Training and OutreachP30GM124169 · NIGMS · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI Gregory L Hura · 2017 to 2026
$28.6M
Mayo Clinic Center for Clinical ProteomicsU01CA271410 · NCI · MAYO CLINIC ROCHESTER · PI Rafael Fonseca, AKHILESH PANDEY · 2022 to 2026
$5.3M
MSTP at Mayo Clinic RochesterT32GM145408 · NIGMS · MAYO CLINIC ROCHESTER · PI SCOTT H KAUFMANN, LISA A SCHIMMENTI · 2023 to 2026
$4.7M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
A Pixel Array Detector System for Small Angle X-ray ScatteringS10OD018483 · OD · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI CLASSEN, SCOTT · 2014 to 2014
$998k
NCI NIH HHS P30 CA015083NCI NIH HHS P50 CA116201NCI NIH HHS U01 CA271410NIGMS NIH HHS P30 GM124165NIGMS NIH HHS P30 GM124169NIGMS NIH HHS T32 GM145408NIH HHS S10 OD018483NIH HHS S10 OD021527U.S. Department of Health & Human Services | National Institutes of Health (NIH) P50CA116201
6 · The paper itself

Abstract

Protein kinase C (PKC) isozymes are ubiquitous kinases that direct diverse cellular pathways and are important drug targets for the treatment of cancer and neurological diseases. PKCs are auto-regulating enzymes governed by phospholipid and Ca

Indexed as

Protein Kinase C betaAllosteric RegulationCrystallography, X-RayHumansIsoenzymesModels, MolecularProtein ConformationProtein Kinase InhibitorsIsoenzymesProtein Kinase C betaProtein Kinase Inhibitors

Identifiers

PMID42168197
PMCPMC13385876

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.