Evidence map›Paper›PMID 42167694›Full record

ArticleJournal of affective disorders2026

Differential cerebral white matter tract alterations in generalized anxiety disorder revealed by ultra-high-field 7 T diffusion-weighted imaging.

Chang-Le Chen, Minjie Wu, Yueyang Chi, Max Rose, Jessica C Weber, Shannon T Lamb, Hecheng Jin, Tamer S Ibrahim, Cecile D Ladouceur, Yue-Fang Chang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Chang-Le ChenDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Minjie WuDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yueyang ChiDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Max RoseDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jessica C WeberDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Shannon T LambDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Hecheng JinDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Tamer S IbrahimDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Cecile D LadouceurDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Yue-Fang ChangDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, PA, USA.
Kuei Y TsengDepartment of Anatomy and Cell Biology, College of Medicine, University of Illinois at Chicago, Chicago, IL, USA.
Howard J AizensteinDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Shaolin YangDepartment of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: yans@pitt.edu.

Funding

Functional and Neurochemical Substrates of Amygdala-Frontal Circuitry across Development and Anxiety (COVID-19 Supplement)R21MH116475 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI YANG, SHAOLIN · 2020 to 2022
$460k
NIMH NIH HHS R21 MH116475
6 · The paper itself

Abstract

Generalized anxiety disorder (GAD) is characterized by chronic worry and emotional dysregulation, yet its underlying white matter (WM) microstructural alterations remain unclear owing to inconsistent findings and technical limitations in prior neuroimaging studies. To address this gap, we employed ultra-high-field 7-Tesla (7 T) diffusion tensor imaging (DTI) and advanced correlational tractography to characterize WM alterations in GAD, examine their associations with symptom burden, and evaluate their diagnostic utility. Eighty-eight young participants (27 with GAD and 61 healthy controls [HCs]) underwent 7 T DTI at 1.5-mm isotropic resolution. Whole-brain correlational tractography was applied to identify WM tracts exhibiting significant group differences in diffusion indices. Associations of identified WM tracts with Hamilton Anxiety Rating Scale (HAM-A) and Penn State Worry Questionnaire (PSWQ) scores were examined, and machine learning-based models were used to assess the diagnostic utility of the WM features. Two right-hemispheric tract alterations were identified in GAD. First, fractional anisotropy (FA) in the right cingulum was significantly elevated in GAD (P

Indexed as

Anxiety DisordersDiffusion Tensor ImagingGeneralized Anxiety DisorderWhite MatterAdultAnisotropyDiffusion Magnetic Resonance ImagingFemaleHumansMaleYoung Adult7 T MRICorrelational tractographyDiffusion tensor imagingGeneralized anxiety disorderWhite matter

Identifiers

PMID42167694
PMCPMC13561388

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.