Evidence map›Paper›PMID 42167672›Full record

ArticleNeuroscience2026

Executive functioning-related behavior and neuronal activation in the thalamic nucleus reuniens in a combined intubation and alcohol third-trimester binge exposure in rats.

Eva A Smith, Natalie L Onesi, Anna Y Klintsova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Eva A SmithDepartment of Psychological & Brain Sciences, University of Delaware, 105 The Green, Wolf Hall, Room 108, Newark, DE 19716, USA.
Natalie L OnesiDepartment of Psychological & Brain Sciences, University of Delaware, 105 The Green, Wolf Hall, Room 108, Newark, DE 19716, USA.
Anna Y KlintsovaDepartment of Psychological & Brain Sciences, University of Delaware, 105 The Green, Wolf Hall, Room 108, Newark, DE 19716, USA. Electronic address: klintsov@udel.edu.

Funding

Hippocampal-thalamo-prefrontal circuitry damage and therapeutic intervention in a model of FASDR01AA027269 · NIAAA · UNIVERSITY OF DELAWARE · PI KLINTSOVA, ANNA Y · 2019 to 2023
$2.0M
Hippocampal-thalamo-prefrontal circuitry damage in an animal model of FASDR21AA026613 · NIAAA · UNIVERSITY OF DELAWARE · PI KLINTSOVA, ANNA Y · 2018 to 2019
$392k
NIAAA NIH HHS R01 AA027269NIAAA NIH HHS R21 AA026613
6 · The paper itself

Abstract

Fetal Alcohol Spectrum Disorders (FASD) result from prenatal alcohol exposure (AE) and are linked to executive functioning (EF) deficits. The nucleus reuniens (Re) of the thalamus facilitates hippocampal-prefrontal synchrony, essential for EF. While AE alters Re structure and function, its role in EF impairments remains unclear. This study examined the effects of third-trimester equivalent AE on Re volume, neuron count and their activation following a Re-dependent object-in-place (OIP) task in adulthood. Using immunohistochemistry for NeuN (neuronal marker) and ΔFosB (sustained activation marker), we assessed AE-induced changes. We found that AE on postnatal days 4-9 led to reduced Re volume, neuron number, and neuronal activation, as indicated by decreased ΔFosB expression. Behaviorally, AE females showed impaired OIP discrimination, whereas males were unaffected. These findings suggest AE-induced Re dysfunction contributes to EF deficits, particularly in females. Additionally, stress from intubation may influence outcomes and warrants further investigation. This study underscores Re's vulnerability to AE and the need for research into sex-specific mechanisms and interventions for AE-related cognitive deficits.

Indexed as

Binge DrinkingEthanolExecutive FunctionFetal Alcohol Spectrum DisordersMidline Thalamic NucleiNeuronsPrenatal Exposure Delayed EffectsAnimalsFemaleMalePregnancyProto-Oncogene Proteins c-fosRatsRats, Long-EvansEthanolFosb protein, ratProto-Oncogene Proteins c-fosExecutive functioningFASDNucleus reuniensObject-in-placePrenatal alcohol exposureThalamus

Identifiers

PMID42167672
PMCPMC13232375

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.