ArticleBrain, behavior, and immunity2026
Diurnal dynamics and psychobiological regulation of cell-free mitochondrial and nuclear DNA in human saliva.
Article in Brain, behavior, and immunity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Saliva cell-free mitochondrial DNA (cf-mtDNA) response during physical and cognitive stress.medRxiv : the preprint server for health sciences · 2026Article
- Saliva cell-free mitochondrial DNA (cf-mtDNA) as a dynamic biomarker of stress and emotion in daily life: Evidence from two independent repeated-measures studies.medRxiv : the preprint server for health sciences · 2026Article
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9 authors.
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Abstract
Cell-free mitochondrial DNA (cf-mtDNA) has emerged as a dynamic molecular signal responsive to psychological stress and a potential biomarker of stress-related physiological adaptations. While previous work has established the acute stress reactivity of cf-mtDNA in saliva, little is known about its diurnal regulation. In this intensive-sampling study, we characterized the diurnal dynamics of saliva cf-mtDNA across one weekday and one weekend day in healthy adults (N = 25, 52% female, 826 samples). Saliva was collected at awakening, during the first hour post-awakening, and at hourly intervals throughout the day. Using a quantitative PCR-based assay, we observed a robust cf-mtDNA awakening response, with concentrations peaking approximately 45 min after waking (2.5-fold change, Cohen's d = 0.90), followed by a second peak at 180 min post-awakening (5.7-fold change, d = 1.70) and relatively stable levels thereafter. Saliva cf-mtDNA closely tracked cell-free nuclear DNA (cf-nDNA) across time points (r
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